PAX-2 (EP235) Rabbit Monoclonal Primary Antibody
SIGMA/311R-1
Product Type: Chemical
antibody form | culture supernatant |
antibody product type | primary antibodies |
biological source | rabbit |
clone | EP235, monoclonal |
conjugate | unconjugated |
description | (For In Vitro Diagnostic Use in Select Regions (See Chart)) |
form | buffered aqueous solution |
isotype | IgG |
manufacturer/tradename | Cell Marque™ |
packaging | bottle of 1.0 mL predilute (311R-17) |
bottle of 7.0 mL predilute (311R-18) | |
vial of 0.1 mL concentrate (311R-14) | |
vial of 0.5 mL concentrate (311R-15) | |
vial of 1.0 mL concentrate (311R-16) | |
Quality Level | 100 |
500 | |
shipped in | wet ice |
species reactivity | human |
storage temp. | 2-8°C |
technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50 |
General description: | PAX-2 is a homeogene strongly expressed during kidney development. PAX-2 gene is expressed in the metanephric mesenchyma after ureter bud induction and is a key factor for the mesenchyma-epithelium conversion. Animals transgenic for PAX-2 have severe renal abnormalities and cysts but no solid tumoral features. The oncogenic potential of the PAX gene family has been reported <em>in vitro</em> with transformation of cell cultures and <em>in vivo</em> with cell injections in nude mice. Gnarra et al. showed PAX-2 expression in renal carcinoma cell lines and underlined its potential role in cell proliferation in these lines.1 Mazal et al. demonstrated PAX-2 nuclear expression in 88% of clear cell renal cell carcinomas as well as 18% of papillary renal cell carcinoma, and 13% of chromophobe renal cell carcinomas.2 More recently, Chivukula et al. demonstrated utility in distinguishing ovarian serous papillary carcinoma (anti-PAX-2 positive) from breast carcinoma (anti-PAX-2 negative).3 | ||||
Legal Information: | Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany | ||||
Linkage: | PAX-2 Positive Control Slides, Product No. 311S , are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). | ||||
Other Notes: | For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com | ||||
Physical form: | Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide. | ||||
Preparation Note: | Download the IFU specific to your product lot and format Note: This requires a keycode which can be found on your packaging or product label. | ||||
Quality: |
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RIDADR | NONH for all modes of transport |
WGK Germany | WGK 2 |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |