CA-125 (OC125) Mouse Monoclonal Antibody
SIGMA/325M-1
Product Type: Chemical
Immunohistochemistry CA 125 (OC125) on ovarian carcinoma
| antibody form | diluted ascites fluid |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | OC125, monoclonal |
| conjugate | unconjugated |
| control | ovarian carcinoma |
| description | For In Vitro Diagnostic Use in Select Regions (See Chart) |
| form | buffered aqueous solution |
| isotype | IgG1κ |
| manufacturer/tradename | Cell Marque™ |
| packaging | bottle of 1.0 mL predilute (325M-17) |
| bottle of 7.0 mL predilute (325M-18) | |
| vial of 0.1 mL concentrate (325M-14) | |
| vial of 0.5 mL concentrate (325M-15) | |
| vial of 1.0 mL concentrate (325M-16) | |
| Quality Level | 100  |
| 500 |
|
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | 2-8°C |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 |
| visualization | cytoplasmic, membranous |
| General description: | CA-125 (cancer antigen 125) is a large transmembrane glycoprotein belonging to the mucin family, encoded by the gene MUC16. By immunohistochemistry, CA-125 expression is not identified in normal ovarian tissue, but it is found in the normal cervix, fallopian tube, and endometrium. Positive immunostaining for CA-125 is seen in most ovarian carcinomas and epithelioid mesotheliomas. Anti-CA-125 antibody reacts with epithelioid malignancies of the ovary, papillary serous carcinoma of the cervix, adenocarcinoma of the endometrium, clear cell adenocarcinoma of the bladder, and epithelioid mesothelioma. The antigen is formalin resistant, permitting the detection of ovarian cancer by immunohistochemistry, although serum assays for this protein are widely used to monitor ovarian cancer. Anti-CA-125 also reacts with antigens in seminal vesicle carcinoma. |
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| Legal Information: | Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany | ||||
| Linkage: | CA-125 Positive Control Slides, Product No. 325S , are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). |
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| Other Notes: | For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com | ||||
| Physical form: | Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide | ||||
| Preparation Note: | Download the IFU specific to your product lot and format  Note: This requires a keycode which can be found on your packaging or product label. |
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| Quality: |
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| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |