Thrombomodulin (1009) Mouse Monoclonal Antibody
SIGMA/339M-1
Product Type: Chemical
Immunohistochemistry Thrombomodulin (1009) on transitional cell carcinoma
| antibody form | culture supernatant |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 1009, monoclonal |
| conjugate | unconjugated |
| control | bladder, mesothelioma |
| description | For In Vitro Diagnostic Use in Select Regions (See Chart) |
| form | buffered aqueous solution |
| isotype | IgG1κ |
| manufacturer/tradename | Cell Marque™ |
| packaging | bottle of 1.0 mL predilute (339M-17) |
| bottle of 7.0 mL predilute (339M-18) | |
| vial of 0.1 mL concentrate (339M-14) | |
| vial of 0.5 mL concentrate (339M-15) | |
| vial of 1.0 mL concentrate (339M-16) | |
| Quality Level | 100  |
| 500 |
|
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | 2-8°C |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 |
| visualization | membranous |
| General description: | Thrombomodulin is a transmembrane glycoprotein composed of 575 amino acids (molecular weight 75 kD with natural anticoagulant properties. It is normally expressed by a restricted number of cells, such as endothelial and mesothelial cells. In addition, synovial lining and syncytiotrophoblasts of human placenta also express thrombomodulin. Several immunohistochemical endothelial markers are currently available and anti-thrombomodulin serves as another such marker, staining blood and lymphatic channels consistently. Anti-thrombomodulin has demonstrated positivity in 100% of benign vascular tumors (pyogenic granuloma and hemangioma) and 94% of malignant vascular tumors (Kaposi’s sarcoma, angiosarcoma, and epithelioid hemangioendothelioma). Hence, anti-thrombomodulin serves as a sensitive marker for lymphatic endothelial cells and their tumors. There has also been recent interest in the use of anti-thrombomodulin as an immunohiostochemical marker for mesothelial cells and malignant mesotheliomas. Anti-thrombomodulin is immunoexpressed in a variety of other tumors including squamous cell carcinomas of the lung, synovial sarcoma, transitional cell carcinoma, renal cell carcinomas and thymomas. | ||||
| Legal Information: | Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany | ||||
| Linkage: | Thrombomodulin Positive Control Slides, Product No. 339S , are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). |
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| Other Notes: | For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com | ||||
| Physical form: | Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide | ||||
| Preparation Note: | Download the IFU specific to your product lot and format  Note: This requires a keycode which can be found on your packaging or product label. |
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| Quality: |
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| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352203 |