TTF-1 (8G7G3/1) Mouse Monoclonal Antibody
SIGMA/343M-9
Product Type: Chemical
antibody form | culture supernatant |
antibody product type | primary antibodies |
biological source | mouse |
clone | 8G7G3/1, monoclonal |
conjugate | unconjugated |
control | lung adenocarcinoma |
description | For In Vitro Diagnostic Use in Select Regions (See Chart) |
form | buffered aqueous solution |
isotype | IgG1 |
manufacturer/tradename | Cell Marque™ |
packaging | bottle of 1.0 mL predilute (343M-97) |
bottle of 7.0 mL predilute (343M-98) | |
vial of 0.1 mL concentrate (343M-94) | |
vial of 0.5 mL concentrate (343M-95) | |
vial of 1.0 mL concentrate (343M-96) | |
Quality Level | 100 |
500 | |
shipped in | wet ice |
species reactivity | human |
storage temp. | 2-8°C |
technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500 |
visualization | nuclear |
General description: | Anti-TTF-1 (Thyroid Transcription Factor 1) is useful in differentiating primary adenocarcinoma of the lung from metastatic carcinomas originating in the organs rather than thyroid, germ cell tumors, and malignant mesothelioma. It can also be used to differentiate small cell lung carcinoma from lymphoid infiltrates. TTF-1 labeling is also seen in thyroid and thyroid-derived tumors TTF-1 immunostaining is useful in the differentiation between pulmonary and nonpulmonary origin of adenocarcinomas in malignant effusions. TTF-1 staining is very reliable in discerning whether a brain metastasis has arisen from a pulmonary or nonpulmonary site, particularly when dealing with adenocarcinomas and large-cell carcinomas. | ||||
General description: | Thyroid transcription factor-1 (TTF-1) is a transcription factor that plays a role in regulating genes expressed within the thyroid, lungs, and brain. TTF-1 expression is present in normal thyroid epithelium and type II pneumocytes and nonciliated bronchiolar secretory cells of the lung. TTF-1 expression is seen in most primary lung and thyroid carcinomas, but rarely in other carcinomas. Anti-TTF-1 immunohistochemistry is useful for identifying carcinomas of thyroid and lung origin. | ||||
Legal Information: | Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany | ||||
Linkage: | TTF-1 Positive Control Slides, Product No. 343S , are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). | ||||
Other Notes: | For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com | ||||
Physical form: | Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide | ||||
Preparation Note: | Download the IFU specific to your product lot and format Note: This requires a keycode which can be found on your packaging or product label. | ||||
Quality: |
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RIDADR | NONH for all modes of transport |
WGK Germany | WGK 2 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |