Cytokeratin 5 & 6 (D5 & 16B4) Mouse Monoclonal Antibody
SIGMA/356M-1
Product Type: Chemical
antibody form | culture supernatant |
antibody product type | primary antibodies |
biological source | mouse |
clone | D5 & 16B4, monoclonal |
conjugate | unconjugated |
control | mesothelioma |
description | For In Vitro Diagnostic Use in Select Regions (See Chart) |
form | buffered aqueous solution |
isotype | IgG1 |
manufacturer/tradename | Cell Marque™ |
packaging | bottle of 1.0 mL predilute (356M-17) |
bottle of 7.0 mL predilute (356M-18) | |
vial of 0.1 mL concentrate (356M-14) | |
vial of 0.5 mL concentrate (356M-15) | |
vial of 1.0 mL concentrate (356M-16) | |
Quality Level | 100 |
500 | |
shipped in | wet ice |
species reactivity | human |
storage temp. | 2-8°C |
technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:200 |
visualization | cytoplasmic |
General description: | Anti-CK 5 & 6 positivity is seen in 65% to 100% of epithelioid mesotheliomas, in 0% to 19% of lung adenocarcinomas, and in 22% to 80% of serous carcinoma of the ovary and peritoneum. Keratin 5 & 6 expression in lung adenocarcinoma is not common, and when it occurs, the reaction is usually confined to small focal areas or scattered cells. The most probable cause of this finding is the presence of squamous differentiation of lung adenocarcinoma. Anti-CK 5 & 6 positivity has been useful in recognizing squamous cell carcinoma of the skin. Less than 10% of carcinomas of the breast, colon, and prostate stain positively for this marker. Anti-CK 5 & 6 has also been used successfully as a myoepithelial cell marker in the prostate and breast to determine malignancy. Anti-CK 5 & 6 is a useful marker to distinguish lung squamous cell carcinoma from lung adenocarcinoma and large cell carcinoma within a panel including antibodies against TTF-1, Napsin A, p63, SOX-2, desmocollin3, and desmoglein3. | ||||
Legal Information: | Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany | ||||
Linkage: | Cytokeratin 5 & 6 Positive Control Slides, Product No. 356S , are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). | ||||
Other Notes: | For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com | ||||
Physical form: | Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide | ||||
Preparation Note: | Download the IFU specific to your product lot and format Note: This requires a keycode which can be found on your packaging or product label. | ||||
Quality: |
|
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 2 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | 2-8°C |
UNSPSC | 12352200 |