Dansyl chloride
SIGMA/39220 - BioReagent, suitable for fluorescence, ≥99.0% (HPLC)
Synonym: 1-
CAS Number: 605-65-2
Empirical Formula (Hill Notation): C12H12ClNO2S
Molecular Weight: 269.75
EC Number: 210-092-6
MDL Number: MFCD00003985
Linear Formula: C12H12ClNO2S
Product Type: Chemical
| assay | ≥99.0% (HPLC) |
| fluorescence | λex 337 nm; λem 492 nm in chloroform (after derivatization with hexylamine) |
| InChI | 1S/C12H12ClNO2S/c1-14(2)1 |
| InChI key | XPDXVDYUQZHFPV-UHFFFAOYSA |
| mp | 72-74 °C (lit.) |
| product line | BioReagent |
| Quality Level | 200  |
| SMILES string | CN(C)c1cccc2c(cccc12)S(Cl |
| solubility | acetone: 0.2 g/10 mL |
| storage temp. | 2-8°C |
| suitability | suitable for fluorescence |
| Application: | A fluorogenic reagent for fluorescent N-terminal derivatization of amino acids and peptides and detection by reverse phase HPLC. |
| Application: | Dansyl Chloride is used as a derivatization reagent to study extensive metabolism and low doses of ethinylestradiol administered during pre-clinical studies. Studies conducted to determine bisphenols in human serum through the HPLC method used Dansyl Chloride to obtain the derivative products. Dansyl Chloride derivatives are suitable for LC/MS determination and characterization of glyphosate, aminomethylphosphonic acid (AMPA), and glufosinate from food samples. |
| General description: | Dansyl Chloride, also known as 5-dimethylamino naphthalene-1-sulfonyl chloride, is a pre-column derivatization reagent. After the derivatization reaction, the fluorescent derivatives are analyzed using several analytical methods like NMR, IR, UV-vis, and fluorescence microscopy. Dansyl Chloride is a typical aromatic sulphonyl chloride that reacts with various bases, resulting in derivatives with variable stability. |
| Symbol |  GHS05 |
| Signal word | Danger |
| Hazard statements | H290 - H314 |
| Precautionary statements | P260 - P280 - P303 + P361 + P353 - P305 + P351 + P338 + P310 |
| Hazard Codes | C |
| Risk Statements | 34 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 3261 8 / PGII |
| WGK Germany | WGK 3 |
| Purity | ≥99.0% (HPLC) |
| mp | 72-74 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352101 |