Pyrimidine nucleoside phosphorylase
SIGMA/39488 - recombinant, expressed in E. coli, ≥1300 U/mL
CAS Number: 9055-35-0
Product Type: Chemical
| form | liquid |
| Quality Level | 100  |
| recombinant | expressed in E. coli |
| relevant disease(s) | cancer |
| specific activity | ≥1300 U/mL |
| storage temp. | −20°C |
| Application: | Pyrimidine nucleoside phosphorylase (PyNPase) may be used as a marker to predict the malignant potential of breast cancer, especially lymph node metastasis. PyNPase is used to study breast cancer, specifically its role in angiogenesis. |
| Biochem/physiol Actions: | Pyrimidine nucleoside phosphorylase (PyNPase) is a glycosyltransferase that catalyzes the conversion of pyrimidine nucleoside and phosphate to a pyrimidine base and α-D-ribose 1-phosphate. PyNPase plays a significant role in breast cancer angiogenesis. |
| Unit Definition: | One unit will convert 1 μmole each of thymidine and phosphate to thymine and 2-deoxyribose 1-phosphate per minute at pH 7.4 and 25°C |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| activity | specific activity: ≥1300 U/mL |
| Storage Temp. | −20°C |
| Enzyme Commission (EC) Number | 2.4.2.2 ( BRENDA  | IUBMB ) |
| UNSPSC | 12352204 |