Parvalbumin (2E11) Mouse Monoclonal Antibody
SIGMA/396M-1
Product Type: Chemical
Immunohistochemistry Parvalbumin (2E11) on chromophobe renal cell carcinoma
| antibody form | culture supernatant |
| antibody product type | primary antibodies |
| biological source | mouse |
| clone | 2E11, monoclonal |
| conjugate | unconjugated |
| control | chromophobe renal cell carcinoma |
| description | For In Vitro Diagnostic Use in Select Regions (See Chart) |
| form | buffered aqueous solution |
| isotype | IgG1 |
| manufacturer/tradename | Cell Marque™ |
| packaging | bottle of 1.0 mL predilute (396M-17) |
| bottle of 7.0 mL predilute (396M-18) | |
| vial of 0.1 mL concentrate (396M-14) | |
| vial of 0.5 mL concentrate (396M-15) | |
| vial of 1.0 mL concentrate (396M-16) | |
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | 2-8°C |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50 |
| visualization | cytoplasmic |
| General description: | Parvalbumin is a calcium-binding protein that regulates cytosolic calcium homeostasis. Tissue types that express this protein have been reported in the muscle, brain, neuroendocrine organs, and kidney.In normal kidney, parvalbumin has been shown to be limited to the distal tubular and collecting duct cells (the intercalated cells). Parvalbumin is strongly expressed in almost all primary, as well as metastatic, chromophobe renal cell carcinoma (RCC) (100%) and oncocytoma (69%), but is essentially negative in other types of RCCs, such as clear cell RCC and papillary RCC. This limited expression has been considered in keeping with the putative histogenesis of chromophobe RCC and oncocytoma from the distal portion of the nephron and may facilitate in their differential diagnoses. | ||||
| Legal Information: | Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany | ||||
| Linkage: | Parvalbumin Positive Control Slides, Product No. 396S  , are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). |
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| Other Notes: | For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com | ||||
| Physical form: | Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide | ||||
| Preparation Note: | Download the IFU specific to your product lot and format  Note: This requires a keycode which can be found on your packaging or product label. |
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| Quality: |
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| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |