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Amentoflavone

SIGMA/40584 - ≥98.0% (HPLC)

Synonym: Didemethyl-ginkgetin; I3′,II8-Biapigenin; Tridemethylsciadopitysin

CAS Number: 1617-53-4
Empirical Formula (Hill Notation): C30H18O10
Molecular Weight: 538.46
MDL Number: MFCD00017470
Linear Formula: C30H18O10
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-40584-1MG-F 1 mg
 $170.00
1/EA		 Add To Favorites
45-40584-5MG-F 5 mg
 $645.00
1/EA		 Add To Favorites

 

application(s) metabolomics
vitamins, nutraceuticals, and natural products
assay ≥98.0% (HPLC)
form solid
InChI 1S/C30H18O10/c31-15-4-1-13(2-5-15)24-12-23(38)29-21(36)10-20(35)27(30(29)40-24)17-7-14(3-6-18(17)33)25-11-22(37)28-19(34)8-16(32)9-26(28)39-25/h1-12,31-36H
InChI key YUSWMAULDXZHPY-UHFFFAOYSA-N
Quality Level 100 
SMILES string Oc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)c(c3O2)-c4cc(ccc4O)C5=CC(=O)c6c(O)cc(O)cc6O5
storage temp. 2-8°C
Application: Amentoflavone has been used:
• as a chemical inhibitor to determine the selective attenuation of p-Cresol glucuronidation in HepaRG cells
• as a reference standard for qualitative and quantitative analyses of phenolic compounds of Juniperus foetidissima Willd. and Juniperus sabina L. using reverse phase- high-performance liquid chromatography- diode array detector (RP-HPLC-DAD)
• as a reference standard to analyze and standardize the methanol extract process of Juniperus drupacea Labill. phenolic compounds using reverse phase- high-performance liquid chromatography - diode array detector (RP-HPLC-DAD)
Biochem/physiol Actions: Amentoflavone has various pharmacological properties such as antioxidant, anti-diabetic, anti-tumor, anti-senescence, neuroprotective, and cardioprotective activities.
Biochem/physiol Actions: Biflavonoid with anti-inflammatory, anti-viral and cancer chemopreventive activity. It inhibits vascularization of tumors by blocking the activity of angiogenic VEGFs. Blocks the induction of COX-2 and up-regulates PPAR-γ. It is a negative modulator of the GABAA receptor at the benzodiazepine binding site.
General description: Amentoflavone is a naturally occurring polyphenolic biflavonoid found in many plants. Structurally, it has an apigenin dimer which is linked by a C3′-C8′′ covalent bond.
Packaging: Bottomless glass bottle. Contents are inside inserted fused cone.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98.0% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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