β-Nicotinamide adenine dinucleotide, reduced disodium salt hydrate

SIGMA/43420 - ≥95.0% (HPLC)

Synonym: β-DPNH; β-NADH; DPNH; Diphosphopyridine nucleotide, reduced form; NADH

CAS Number: 606-68-8 (anhydrous)
Empirical Formula (Hill Notation): C₂₁H₂₇N₇Na₂O₁₄P₂ · xH₂O
Molecular Weight: 709.40 (anhydrous basis)
EC Number: 210-123-3
MDL Number: MFCD03791273
Linear Formula: C₂₁H₂₇N₇Na₂O₁₄P₂ · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-43420-100MG	100 mg	$52.30 1/EA	Add To Favorites
45-43420-1G	1 g	$191.00 1/EA	Add To Favorites
45-43420-5G	5 g	$759.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

absorbance ratio	A_260/340 nm ≤2.40
assay	≥95.0% (HPLC)
cation traces	Ca: ≤200 mg/kg
	Cd: ≤5 mg/kg
	Co: ≤5 mg/kg
	Cr: ≤5 mg/kg
	Cu: ≤20 mg/kg
	Fe: ≤5 mg/kg
	K: ≤200 mg/kg
	Mg: ≤200 mg/kg
	Mn: ≤5 mg/kg
	Ni: ≤5 mg/kg
	Pb: ≤5 mg/kg
	Zn: ≤5 mg/kg
form	powder
InChI	1S/C21H29N7O14P2.2Na.H2O/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33;;;/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25);;;1H2/q;2*+1;/p-2/t10-,11-,13-,14-,15-,16-,20-,21-;;;/m1.../s1
InChI key	FWBNCIFELNNJCX-UHOVGGJYSA-L
Quality Level	200
SMILES string	O.[Na+].[Na+].NC(=O)C1=CN(C=CC1)[C@@H]2O[C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O
storage temp.	−20°C

Application:	As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.
Application:	Nicotinamide adenine dinucleotide (NAD) and NADH form a redox pair. NAD/NADH is a coenzyme that supports redox reactions via the transport of electrons in a vast array of applications. NAD is also involved in post-translational (Poly(ADP-ribose) polymerization) modifications of proteins.
Biochem/physiol Actions:	NADH is a coenzyme that functions as a regenerating electron donor in catabolic processes including glycolysis, β-oxidation and the citric acid cycle (Krebs cycle, TCA cycle). It participates in cell signaling events as well, for example as a substrate for the poly (ADP-ribose) polymerases (PARPs) during the DNA damage response. The NAD⁺/NADH dependent sirtuins play key roles in stress responses during events involving energy metabolism, with implications in cancer biology, diabetes and neurodegenerative disease. As a reagent, NADH can be used in enzyme cycling assays to amplify detection of activity of biologically relevant enzymes or metabolites present in low concentrations.
Packaging:	Packaged by solid weight.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95.0% (HPLC)
Storage Temp.	−20°C
UNSPSC	41106305

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