ERG (EP111) Rabbit Monoclonal Primary Antibody
SIGMA/434R-1
Product Type: Chemical
Immunohistochemistry ERG (EP111) on prostate adenocarcinoma
| antibody form | culture supernatant |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | EP111, monoclonal |
| conjugate | unconjugated |
| control | tonsil |
| description | (For In Vitro Diagnostic Use in Select Regions (See Chart)) |
| form | buffered aqueous solution |
| isotype | IgG |
| manufacturer/tradename | Cell Marque™ |
| packaging | bottle of 1.0 mL predilute (434R-17) |
| bottle of 7.0 mL predilute (434R-18) | |
| vial of 0.1 mL concentrate (434R-14) | |
| vial of 0.5 mL concentrate (434R-15) | |
| vial of 1.0 mL concentrate (434R-16) | |
| Quality Level | 100  |
| 500 |
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| shipped in | wet ice |
| species reactivity | human |
| storage temp. | 2-8°C |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:200 |
| visualization | nuclear |
| General description: | ERG is a member of the erythroblastosis virus E26 transforming sequence (ETS) transcription factor gene family, which also includes Fli-1 and ETS-1.1-5 ERG is expressed in lymphocytes and endothelial cells and regulates endothelial apoptosis and angiogenesis. ERG has been found to be expressed in both benign and malignant vascular tumors. Anti-ERG was found to have high sensitivity for vascular neoplasms.1 ERG expression has been observed in prostate carcinomas and high-grade prostatic intraepithelial neoplasia (HGPIN).1-4 ERG positivity in any other epithelial tumor other than prostate carcinoma is extremely rare. In a study of all carcinomas of the breast, gastrointestinal tract, gynecologic system, kidney, lung, ovary, pancreas, salivary glands, skin, thyroid, and testis were negative for ERG.1 ERG has also been observed to be positive in a minority of Ewing sarcomas.2 This is caused by a chromosomal rearrangement which fuses the EWSR1 gene with the ERG gene (EWSR 1:ERG).5 ERG has also been observed to stain some meningiomas due to cross reactivity with Fli-1.1 | ||||
| Legal Information: | Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany | ||||
| Linkage: | ERG Positive Control Slides, Product No. 434S , are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). |
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| Other Notes: | For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com | ||||
| Physical form: | Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide. | ||||
| Preparation Note: | Download the IFU specific to your product lot and format  Note: This requires a keycode which can be found on your packaging or product label. |
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| Quality: |
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| RIDADR | NONH for all modes of transport |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |