Doxorubicin hydrochloride

SIGMA/44583 - suitable for fluorescence, 98.0-102.0% (HPLC)

Synonym: DOX; Hydroxydaunorubicin hydrochloride

CAS Number: 25316-40-9
Empirical Formula (Hill Notation): C₂₇H₂₉NO₁₁ · HCl
Molecular Weight: 579.98
EC Number: 246-818-3
MDL Number: MFCD00077757
Linear Formula: C₂₇H₂₉NO₁₁ · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-44583-1MG	1 mg	$62.50 1/EA	Add To Favorites
45-44583-10MG	10 mg	$319.00 1/EA	Add To Favorites
45-44583-50MG	50 mg	$1120.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 44583-10MG

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	neoplastics
assay	98.0-102.0% (HPLC)
biological source	synthetic
color	orange to dark red
fluorescence	λ_em 580-590 nm
form	solid
InChI	1S/C27H29NO11.ClH/c1-10-22(31)13(28)6-17(38-10)39-15-8-27(36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23(32)11-4-3-5-14(37-2)18(11)25(21)34;/h3-5,10,13,15,17,22,29,31,33,35-36H,6-9,28H2,1-2H3;1H/t10-,13-,15-,17-,22+,27-;/m0./s1
InChI key	MWWSFMDVAYGXBV-RUELKSSGSA-N
mode of action	DNA synthesis \| interferes
	enzyme \| inhibits
mp	216 °C (dec.) (lit.)
Quality Level	200
SMILES string	Cl[H].COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
solubility	DMSO: soluble
	ethanol: soluble
	H₂O: 50 mg/mL, clear, orange to red
	methanol: soluble
	THF: soluble
storage temp.	2-8°C
suitability	suitable for fluorescence

Application:	Doxorubicin was used to induce apoptosis, and to induce cardiotoxicity in SK-N-MC cells . It is used to inhibit macromolecular biosynthesis.
Biochem/physiol Actions:	Doxorubicin ia an antitumor antibiotic that intercalates DNA and inhibits macromolecular biosynthesis. DNA replication is haulted due to the inhibition of topoisomerase II. It is an inhibitor of reverse transcriptase and RNA polymerase and is an immunosuppressive agent .
General description:	Chemical structure: tetracycline
Other Notes:	Keep container tightly closed in a dry and well-ventilated place.
Packaging:	1, 10, 50 mg in glass bottle
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.

Symbol	GHS07,GHS08
Signal word	Danger
Hazard statements	H302 - H340 - H350 - H360FD
Precautionary statements	P201 - P202 - P264 - P270 - P301 + P312 - P308 + P313
Hazard Codes	T,Xi
Risk Statements	45-22-36/38
Safety Statements	53-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	98.0-102.0% (HPLC)
mp	216 °C (dec.) (lit.)
Storage Temp.	2-8°C
UNSPSC	51101500

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