Acitretin

SIGMA/44707 - ≥98.0% (HPLC)

Synonym: 9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethylnona-2,4,6,8-tetraenoic acid

CAS Number: 55079-83-9
Empirical Formula (Hill Notation): C₂₁H₂₆O₃
Molecular Weight: 326.43
EC Number: 259-474-4
MDL Number: MFCD00866632
Linear Formula: C₂₁H₂₆O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-44707-25MG	25 mg	$176.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98.0% (HPLC)
form	powder
InChI	1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23)/b9-7+,11-10+,14-8+,15-12+
InChI key	IHUNBGSDBOWDMA-AQFIFDHZSA-N
Quality Level	100
SMILES string	COc1cc(C)c(C=CC(C)=CC=CC(C)=CC(O)=O)c(C)c1C

Application:	Acitretin, a retinoid that binds to nuclear receptors and regulates gene expression, is a potent activator of the α-secretase ADAM10 gene expression and apoptosis inducer via the CD95 signalling pathway. Acitretin is a systemic retinoid drug used in the treatment of severe psoriasis.
Biochem/physiol Actions:	Synthetic retinoid that is a metabolite of etretinate. Preferentially binds to cellular retinoic acid binding proteins (CRABPs).

Symbol	GHS07,GHS08,GHS09
Signal word	Danger
Hazard statements	H315 - H319 - H360 - H410
Precautionary statements	P201 - P273 - P302 + P352 - P305 + P351 + P338 - P308 + P313
Hazard Codes	T,N
Risk Statements	61-36/38-50/53
Safety Statements	53-26-45-60-61
RIDADR	UN 3077 9 / PGIII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98.0% (HPLC)
UNSPSC	12352200

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