p53 (SP5) Rabbit Monoclonal Antibody
SIGMA/453R-1
Product Type: Chemical
Immunohistochemistry p53 (SP5) on ovarian carcinoma
| antibody form | culture supernatant |
| antibody product type | primary antibodies |
| biological source | rabbit |
| clone | SP5, monoclonal |
| conjugate | unconjugated |
| control | colon carcinoma |
| description | For In Vitro Diagnostic Use in Select Regions (See Chart) |
| form | buffered aqueous solution |
| isotype | IgG1 |
| manufacturer/tradename | Cell Marque™ |
| packaging | bottle of 1.0 mL predilute (453R-17) |
| bottle of 7.0 mL predilute (453R-18) | |
| vial of 0.1 mL concentrate (453R-14) | |
| vial of 0.5 mL concentrate (453R-15) | |
| vial of 1.0 mL concentrate (453R-16) | |
| Quality Level | 100  |
| 500 |
|
| shipped in | wet ice |
| species reactivity | human |
| storage temp. | 2-8°C |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 |
| visualization | nuclear |
| General description: | Anti-p53 tumor suppressor protein antibody recognizes a 53 kDa phosphoprotein, identified as p53 suppressor gene product. It reacts with the mutant as well as wild type p53, although significant accumulation of the mutant form of p53 protein due to longer half-life half-life is the basis for the test using the IHC technique. Quantitation of nuclear staining with this antibody has been shown to be a factor in breast carcinoma, lung carcinoma, colorectalcarcinoma, urothelial carcinoma, and ependymoma. p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. |
| Legal Information: | Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany |
| Linkage: | p53 Positive Control Slides, Product No. 453S , are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). |
| Other Notes: | For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com |
| Physical form: | Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide |
| Preparation Note: | Download the IFU specific to your product lot and format  Note: This requires a keycode which can be found on your packaging or product label. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |