5-Fluoro-L-tryptophan
SIGMA/47568 - ≥98.0% (HPLC)
CAS Number: 16626-02-1
Empirical Formula (Hill Notation): C11H11FN2O2
Molecular Weight: 222.22
MDL Number: MFCD00066470
Linear Formula: C11H11FN2O2
Product Type: Chemical
assay | ≥98.0% (HPLC) |
form | powder |
InChI | 1S/C11H11FN2O2/c12-7-1-2- |
InChI key | INPQIVHQSQUEAJ-VIFPVBQESA |
mp | 270-280 °C |
optical purity | enantiomeric ratio: ≥99.5:0.5 (HPLC) |
SMILES string | N[C@@H](Cc1c[nH]c2ccc(F)c |
storage temp. | 2-8°C |
Application: | Exogenous 5-fluoro-Trp is incorporated into proteins in normal protein synthesis. Since 19F is a useful reporter group, this provides a method for studying enzyme mechanisms by NMR. |
Biochem/physiol Actions: | 5-Fluoro-Trp is nonspecifically cytotoxic. It is believed this is due to malfunctioning enzymes that have had replacements of Trp residues by 5-fluoro-Trp. However, at least one case is known where 5-fluoro-Trp substitution leads to significantly greater catalytic activity. |
Packaging: | 25 mg in poly bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥98.0% (HPLC) |
mp | 270-280 °C |
Storage Temp. | 2-8°C |
UNSPSC | 12352202 |