Formononetin
SIGMA/47752 - ≥99.0% (TLC)
Synonym: 7-
CAS Number: 485-72-3
Empirical Formula (Hill Notation): C16H12O4
Molecular Weight: 268.26
EC Number: 207-623-9
MDL Number: MFCD00016948
Linear Formula: C16H12O4
Product Type: Chemical
| application(s) | metabolomics vitamins, nutraceuticals, and natural products |
| assay | ≥99.0% (TLC) |
| form | solid |
| InChI | 1S/C16H12O4/c1-19-12-5-2- |
| InChI key | HKQYGTCOTHHOMP-UHFFFAOYSA |
| mp | 257-261 °C |
| Quality Level | 100  |
| SMILES string | COc1ccc(cc1)C2=COc3cc(O)c |
| Application: | Formononetin has been used: • as a reference standard to study export of multiple metabolites from Crocus sativus stigma extracts using liquid chromatography-photodiode array-high resolution mass spectrometry (LC-PDA-HRMS) • as phytoestrogen-mimetic isoflavones to test its antioxidant effects in a biomimetic environment using chemiluminescence method • as an authentic standard to test the isoflavones content level in both wild type and transgenic Medicago truncatula plant using high-performance liquid chromatography (HPLC) • to test its effects as a potential Aryl hydrocarbon receptor (AhR)-agonist on the restoration of skin barrier proteins for Atopic dermatitis (AD) treatment using different keratinocyte cell lines and human skin equivalent (HSE) model |
| Biochem/physiol Actions: | Formononetin elicits antioxidant, anti-inflammatory, anti-hyperlipidemic, and cardioprotective effects. It displays antidiabetic properties known to be effective against diabetic nephropathy in type 2 diabetes mellitus. Formononetin is a well-known anti-cancer and chemotherapeutic agent that is used in cancer therapy. It also displays antimicrobial, neuroprotective, and anti-hypertensive properties. |
| Biochem/physiol Actions: | Isoflavone found in red clover. Effective against Giardia lamblia infection, at least partially by inducing detachment of trophozoites from intestinal mucosa. |
| General description: | Formononetin is an O-methylated isoflavone, a phytoestrogen. It can be found in many legumes, different species of clovers primarily in Trifolium pratense L. (red clovers), and one of the main flavonoids found in Astragalus membranaceus (Huangqi). |
| Packaging: | Bottomless glass bottle. Contents are inside inserted fused cone. |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99.0% (TLC) |
| mp | 257-261 °C |
| UNSPSC | 12352200 |