Gentamicin sulfate from Micromonospora purpurea

SIGMA/48760 - ≥590 μg/mg of gentamicin

Synonym: Gentamicin C1

CAS Number: 1405-41-0
EC Number: 215-778-9
MDL Number: MFCD00270181
Linear Formula: C_19-21H_39-43N₅O₇ · 2.5H₂SO₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-48760-1G-F	1 g	$120.00 1/EA		Add To Favorites
45-48760-5G-F	5 g	$369.00 1/EA		Add To Favorites
45-48760-25G-F	25 g	$1290.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
	mycoplasma
biological source	Micromonospora purpurea
color	white to off-white
form	powder
InChI	1S/C21H43N5O7.C20H41N5O7.C19H39N5O7.H2O4S/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20;1-8(21)12-5-4-9(22)18(30-12)31-15-10(23)6-11(24)16(13(15)26)32-19-14(27)17(25-3)20(2,28)7-29-19;1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h9-20,25-29H,5-8,22-24H2,1-4H3;8-19,25-28H,4-7,21-24H2,1-3H3;8-18,24-27H,3-7,20-23H2,1-2H3;(H2,1,2,3,4)/t9-,10-,11+,12-,13+,14+,15-,16-,17+,18-,19-,20-,21+;8-,9-,10+,11-,12+,13+,14-,15-,16+,17-,18-,19-,20+;8-,9+,10-,11+,12-,13+,14+,15-,16+,17+,18+,19-;/m110./s1
InChI key	RDEIXVOBVLKYNT-HDZPSJEVSA-N
loss	≤18.0% loss on drying
mode of action	protein synthesis \| interferes
mol wt	M_r 694-723
optical activity	[α]/D 107.0 to 121.0°, c = 10% in H₂O
pH	3.5-5.5 (4% in H₂O)
Quality Level	200
SMILES string	OS(O)(=O)=O.CN[C@@H]1[C@@H](O)[C@H](OC[C@]1(C)O)O[C@H]2[C@H](N)C[C@H](N)[C@@H](O[C@H]3O[C@H](CN)CC[C@H]3N)[C@@H]2O.CN[C@@H]4[C@@H](O)[C@H](OC[C@]4(C)O)O[C@H]5[C@H](N)C[C@H](N)[C@@H](O[C@H]6O[C@@H](CC[C@H]6N)[C@@H](C)N)[C@@H]5O.CN[C@H](C)[C@@H]7CC[C@@H](N)[C@H](O7)O[C@@H]8[C@@H](N)C[C@@H](N)[C@H](O[C@H]9OC[C@](C)(O)[C@H](NC)[C@H]9O)[C@H]8O
specific activity	≥590 μg/mg of gentamicin
storage temp.	2-8°C

Application:	Used as a selection agent (gentamicin-resistance gene) in molecular biology applications. It inhibits the growth of a wide variety of grampositive and gram-negative microorganisms including strains resistant to tetracycline, chloramphenicol, kanamycin and colistin, particularly strains of Pseudomonas, Proteus, Staphylococcus and Streptococcus.
Biochem/physiol Actions:	Mode of Action: Inhibits protein synthesis by binding to L6 protein of 50S ribosomal subunit. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria, and mycoplasma.
General description:	Chemical structure: aminoglycoside
Other Notes:	Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.
Packaging:	1g, 5g, 25g
Preparation Note:	Freely soluble in water, practically insoluble in alcohol and ether.
Unit Definition:	1 U corresponds to 1 μg of the USP gentamicin sulfate reference standard

Symbol	GHS07
Signal word	Warning
Hazard statements	H317
Precautionary statements	P280 - P302 + P352
Hazard Codes	Xn
Risk Statements	42/43
Safety Statements	22-36/37-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

activity	specific activity: ≥590 μg/mg of gentamicin
Storage Temp.	2-8°C
UNSPSC	51101500

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