Gly-Gly-Gly
SIGMA/50239 - BioUltra, ≥99.0% (NT)
Synonym: Glycyl-
CAS Number: 556-33-2
Empirical Formula (Hill Notation): C6H11N3O4
Molecular Weight: 189.17
EC Number: 209-122-0
MDL Number: MFCD00036223
Linear Formula: NH2CH2CONHCH2CONHCH2COOH
Product Type: Chemical
| λ | 0.5 M in H2O |
| anion traces | chloride (Cl-): ≤50 mg/kg |
| sulfate (SO42-): ≤50 mg/kg | |
| assay | ≥99.0% (NT) |
| cation traces | Al: ≤5 mg/kg |
| As: ≤0.1 mg/kg | |
| Ba: ≤50 mg/kg | |
| Bi: ≤5 mg/kg | |
| Ca: ≤20 mg/kg | |
| Cd: ≤5 mg/kg | |
| Co: ≤5 mg/kg | |
| Cr: ≤5 mg/kg | |
| Cu: ≤5 mg/kg | |
| Fe: ≤5 mg/kg | |
| K: ≤50 mg/kg | |
| Li: ≤5 mg/kg | |
| Mg: ≤5 mg/kg | |
| Mn: ≤5 mg/kg | |
| Mo: ≤5 mg/kg | |
| Na: ≤50 mg/kg | |
| Ni: ≤5 mg/kg | |
| Pb: ≤5 mg/kg | |
| Sr: ≤5 mg/kg | |
| Zn: ≤5 mg/kg | |
| color | white |
| form | powder |
| ign. residue | ≤0.1% (as SO4) |
| impurities | insoluble matter, passes filter test |
| InChI | 1S/C6H11N3O4/c7-1-4(10)8- |
| InChI key | XKUKSGPZAADMRA-UHFFFAOYSA |
| loss | ≤0.5% loss on drying, 110 °C |
| pH | 4.5-6.0 (25 °C, 0.5 M in H2O) |
| product line | BioUltra |
| Quality Level | 100  |
| SMILES string | NCC(=O)NCC(=O)NCC(O)=O |
| solubility | H2O: 0.5 M at 20 °C, clear, colorless |
| technique(s) | ligand binding assay: suitable |
| UV absorption | λ: 260 nm Amax: 0.15 |
| λ: 280 nm Amax: 0.10 |
| Amino Acid Sequence: | Gly-Gly-Gly |
| Application: | <ul> <li><strong>Targeting PEPT1: a novel strategy to improve the antitumor efficacy of doxorubicin in human hepatocellular carcinoma therapy:</strong> Research explores Gly-Gly-Gly peptides as potential enhancers for drug transport efficiency, positioning them as valuable tools in clinical diagnostic peptide development for targeted cancer therapies (Gong et al., 2017)  .</li><li><strong>Iminopyridine complexes of manganese, rhenium, and molybdenum derived from amino ester methylserine and peptides Gly-Gly, Gly-Val, and Gly-Gly-Gly: self-assembly of the peptide chains:</strong> This study demonstrates the use of Gly-Gly-Gly in the synthesis of complex metal-peptide frameworks for potential use in high-purity peptide applications in IVD manufacturing (Álvarez et al., 2012) .</li></ul> |
| Biochem/physiol Actions: | Substrate for reproducible serum protein measurements by the biuret reaction and for the assay of aminotripeptidases. |
| General description: | Gly-Gly-Gly or triglycine is a flexible peptide linker with three glycine residues linked by peptide bonds in a linear sequence. Gly-linkers link multiple domains in a single protein without affecting the function of each domain. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99.0% (NT) |
| UNSPSC | 12352209 |