Gramicidin A from Bacillus brevis
SIGMA/50845
CAS Number: 11029-61-1
EC Number: 234-259-8
MDL Number: MFCD00466944
Product Type: Chemical
antibiotic activity spectrum | Gram-negative bacteria |
Gram-positive bacteria | |
biological source | Bacillus brevis |
color | white to off-white |
form | solid |
InChI | 1S/C99H140N20O17/c1-51(2) |
InChI key | ZWCXYZRRTRDGQE-LUPIJMBPSA |
mode of action | cell membrane | interferes |
enzyme | inhibits | |
Quality Level | 100 |
SMILES string | CC(C)C[C@@H](NC(=O)[C@H]( |
storage temp. | 2-8°C |
Amino Acid Sequence: | HCO-X-Gly- |
Application: | Gramicidin A is used for studies on bacterial cell wall permeabilization and monovalent cation channel formation. Gramicidin has also been shown to inhibit transcription of T7 phage DNA, inhibit membrane-bound epidennal adenosine triphosphatase, suppress human lymphocyte blastogenesis in vitro and prolong heart allograft survival in the rat model . It has also been used to study its role in phospholipids adsorption during air-water interface. |
Biochem/physiol Actions: | Gramicidin A increases the permeability of bacterial cell membranes, which allows inorganic monovalent cations to travel through unrestricted. This destroys the ion gradient between the cytoplasm and the extracellular environment . Gramicidin A acts as neutral carrier and helps in the establishment of ion flux across the lipid bilayer. |
Biochem/physiol Actions: | Gramicidin A is a polypeptide antibiotic that forms single ion monovalent cation channels in biological membranes. |
General description: | Chemical structure: peptide |
General description: | Gramicidin A is a linear pentadecapeptide antibiotic produced by Bacillus brevis. The transmembrane protein contains a left-handed helix with alternating |
Other Notes: | Keep container tightly closed in a dry and well-ventilated place.Moisture sensitive. Store under inert gas. Keep in a dry place. |
Packaging: | 100mg |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P264 - P270 - P301 + P312 + P330 - P501 |
Hazard Codes | Xn |
Risk Statements | 22 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | 2-8°C |
UNSPSC | 51101500 |