Guanosine 5′-diphosphate disodium salt

SIGMA/51060 - ≥90% (HPLC)

Synonym: 5′-GDP-Na₂

CAS Number: 7415-69-2
Empirical Formula (Hill Notation): C₁₀H₁₃N₅Na₂O₁₁P₂
Molecular Weight: 487.16
EC Number: 231-026-2
MDL Number: MFCD00084665
Linear Formula: C₁₀H₁₃N₅Na₂O₁₁P₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-51060-100MG	100 mg	$203.00 1/EA		Add To Favorites
45-51060-500MG	500 mg	$700.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥90% (HPLC)
biological source	microbial (Corynebacterium sp)
	Porcine brain
	synthetic
form	powder
InChI	1S/C10H15N5O11P2.2Na/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18);;/q;2*+1/p-2/t3-,5-,6-,9-;;/m1../s1
InChI key	LTZCGDIGAHOTKN-LGVAUZIVSA-L
Quality Level	100
shipped in	dry ice
SMILES string	[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1
solubility	H₂O: 50 mg/mL, clear, colorless
storage temp.	−20°C

Application:	Guanosine 5′-diphosphate (GDP) is used as a substrate of pyruvate kinase to produce GTP in support of RNA biosyntheis. GDP is used to study the kinetics and characteristics of GTPases such as those associated with G-protein coupled receptors (GPCR). GDP is also used to study cell signaling processes mediate by guanine nucleotide exchange factors.
Application:	Guanosine 5′-diphosphate disodium salt has been used: • in fluorescent metal nanoclusters selectivity of guanosine 3′-diphosphate-5′-di(tri)phosphate, ppGpp • in screening of fluorescence emission of hypocrellin A-zinc complex • as a component of assay buffers in the autoradiography of mice brain sections
Biochem/physiol Actions:	Guanosine based nucleosides play a key role in multiple cellular processes and generation growth factors. Elevated levels of guanosine 5′-diphosphate (GDP) is associated with the pathogenesis of neurological disorders. GDP is bound to G protein . G protein coupled receptors (GPCRs) activate G proteins by exchanging the bound GDP to GTP. GDP is potent inhibitor agent of hepcidin- ferroportin complex and may be effective for promoting erythropoiesis and treating anemia of inflammation(AI).
General description:	Guanosine 5′-diphosphate (GDP) is a purine nucleotide and is interconvertible to guanosine by the action of ectonucleotidases and by nucleoside phosphorylase into guanine. GDP is majorly acted upon by 5′‐ectonucleotidases in neuronal cells.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥90% (HPLC)
Storage Temp.	−20°C
UNSPSC	41106305

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