Hemin
SIGMA/51280 - BioXtra, from Porcine, ≥96.0% (HPLC)
Synonym: Chloro(protoporphyrinato)
CAS Number: 16009-13-5
Empirical Formula (Hill Notation): C34H32ClFeN4O4
Molecular Weight: 651.94
EC Number: 240-140-1
MDL Number: MFCD00010726
Linear Formula: C34H32ClFeN4O4
Product Type: Chemical
assay | ≥96.0% (HPLC) |
biological source | Porcine |
form | powder or crystals |
InChI | 1S/C34H34N4O4.ClH.Fe/c1-7 |
InChI key | BTIJJDXEELBZFS-HXFTUNQESA |
product line | BioXtra |
Quality Level | 200 |
SMILES string | Cc1c(CCC(O)=O)c2cc3c(CCC( |
storage temp. | 2-8°C |
technique(s) | tissue culture: suitable |
transfection: suitable |
Application: | Hemin is used for the following applications: • To study bacterial strains and growth conditions • Used in short-term colony assays (the culture medium consists of hemin along with other components) • Cell transfections It may be used in β-hematin formation assay for analyzing the inhibitory activity of MMV (Medicines for Malaria Venture) Malaria Box compounds against the formation of β-hematin. |
Biochem/physiol Actions: | Hemin, the oxidized version of heme, is an iron-containing prosthetic group for a diverse group of proteins. Free heme, which can be released from hemoglobin following hemolysis, is pro-inflammatory and contributes to iron-derived reactive oxygen species. Free hemin levels may be upregulated in various pathological conditions and can contribute to various inflammatory conditions including vascular disorders, renal failure, and immune-mediated disorders. Hemin may be used to study the expression and represson of heme oxygenase 1 (HO-1) as well as the activity of HO-1. Hematin is the "X factor" required to grown Haemophilus influenzae. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥96.0% (HPLC) |
Storage Temp. | 2-8°C |
UNSPSC | 12352202 |