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Monascin

SIGMA/52442 - ≥97.0% (HPLC)

Synonym: (3S,3aR,9aR)-3-Hexanoyl-9a-methyl-6-((E)-propenyl)-3a,4,8,9a-tetrahydro-3H-furo[3,2-g]isochromene-2,9-dione; (3S,3aR,9aR)-3a,4,8,9a-Tetrahydro-9a-methyl-3-(1-oxohexyl)-6-(1E)-1-propenyl-2H-furo[3,2-g][2]benzopyran-2,9(3H)-dione; Monascoflavin

CAS Number: 21516-68-7
Empirical Formula (Hill Notation): C21H26O5
Molecular Weight: 358.43
MDL Number: MFCD09260177
Linear Formula: C21H26O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-52442-1MG 1 mg
 $576.00
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application(s) metabolomics
vitamins, nutraceuticals, and natural products
assay ≥97.0% (HPLC)
form solid
InChI 1S/C21H26O5/c1-4-6-7-9-17(22)18-16-11-13-10-14(8-5-2)25-12-15(13)19(23)21(16,3)26-20(18)24/h5,8,10,16,18H,4,6-7,9,11-12H2,1-3H3/b8-5+/t16-,18+,21-/m1/s1
InChI key XXKNHBAFFJINCK-RVEJDSBJSA-N
Quality Level 100 
SMILES string CCCCCC(=O)[C@@H]1[C@H]2CC3=C(COC(C=CC)=C3)C(=O)[C@]2(C)OC1=O
storage temp. 2-8°C
Application: Monascin has been used to treat 4T1 breast cancer cells and to test its effects on tumor cells anoikis and growth prevention.
Biochem/physiol Actions: Monascin (MS) exerts anti-diabetic and antioxidant properties and provides hyperglycemia control, tissue protection, and thermotolerance in diabetic rats and C. elegans, respectively. It also displays antitumor activity and inhibits Alzheimer′s disease-related tau protein aggregation. Monascin up-regulates high-density lipoprotein cholesterol (HDL-C) levels in hyperlipidemic hamsters model and possesses hypolipidemic properties. It may also possess hepatoprotective effects.
Biochem/physiol Actions: Monascin is one of the azaphilonoid pigments in extracts of Monascus pilosus-fermented rice (red-mold rice). It is a potent inhibitor of carcinogenesis measured against chemical or UV initiated, phorbol-promoted mouse skin tumors.
General description: Monascin is one of the major yellow pigments found in red mold rice. It is structurally similar to ankaflavin.
Packaging: Bottomless glass bottle. Contents are inside inserted fused cone.
RIDADR NONH for all modes of transport
WGK Germany WGK 2
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97.0% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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