7α-Hydroxy-4-cholesten-3-one

SIGMA/52853 - ≥95.0% (HPLC)

Synonym: 7α-Hydroxycholest-4-en-3-one

CAS Number: 3862-25-7
Empirical Formula (Hill Notation): C₂₇H₄₄O₂
Molecular Weight: 400.64
MDL Number: MFCD00870345
Linear Formula: C₂₇H₄₄O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-52853-1MG	1 mg	$397.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

application(s)	clinical testing
assay	≥95.0% (HPLC)
format	neat
grade	analytical standard
InChI	1S/C27H44O2/c1-17(2)7-6-8-18(3)21-9-10-22-25-23(12-14-27(21,22)5)26(4)13-11-20(28)15-19(26)16-24(25)29/h15,17-18,21-25,29H,6-14,16H2,1-5H3/t18-,21-,22+,23+,24-,25+,26+,27-/m1/s1
InChI key	IOIZWEJGGCZDOL-RQDYSCIWSA-N
Quality Level	100
SMILES string	O=C1CC[C@@]2(C)C(C[C@@H](O)[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4([H])[C@H](C)CCCC(C)C)=C1
storage temp.	−20°C

Application:	C4 may be used as a reference standard for the determination of C4 in: • Human serum by ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) with electrospray ionization source (ESI) as well as LC-MS. • Rat and monkey plasma by LC-ESI-MS/MS working on multiple reaction monitoring (MRM) mode of detection. • Peripheral blood plasma by solid-phase extraction (SPE) and HPLC.
Biochem/physiol Actions:	7a-Hydroxycholestene-3-one, a metabolite in bile acid synthesis, is derived from 7a-hydroxycholesterol and can be further metabolized to 7a,12a,-dihydroxycholest-4-en-3-one. Analysis of 7a-Hydroxycholestene-3-one (HCO) in serum may serve as a novel, simple, and sensitive method for the detection of bile acid malabsorption in patients with chronic diarrhea of unknown origin.
General description:	7α-Hydroxy-4-cholesten-3-one (C4) is known as a marker for the cholesterol 7α-hydroxylase activity. It plays an important role in bile acid metabolism.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95.0% (HPLC)
Storage Temp.	−20°C
UNSPSC	41116107

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