Histamine dihydrochloride
SIGMA/53300 - ≥99.0% (AT)
Synonym: 2-
CAS Number: 56-92-8
Empirical Formula (Hill Notation): C5H9N3 · 2HCl
Molecular Weight: 184.07
EC Number: 200-298-4
MDL Number: MFCD00012703
Linear Formula: C5H9N3 · 2HCl
Product Type: Chemical
anion traces | sulfate (SO42-): ≤200 ppm |
assay | ≥99.0% (AT) |
cation traces | Ca: ≤10 mg/kg |
Cd: ≤5 mg/kg | |
Co: ≤5 mg/kg | |
Cr: ≤5 mg/kg | |
Cu: ≤5 mg/kg | |
Fe: ≤5 mg/kg | |
K: ≤50 mg/kg | |
Mg: ≤5 mg/kg | |
Mn: ≤5 mg/kg | |
Na: ≤50 mg/kg | |
Ni: ≤5 mg/kg | |
Pb: ≤5 mg/kg | |
Zn: ≤5 mg/kg | |
form | powder or crystals |
ign. residue | ≤0.2% |
InChI | 1S/C5H9N3.2ClH/c6-2-1-5-3 |
InChI key | PPZMYIBUHIPZOS-UHFFFAOYSA |
loss | ≤0.2% loss on drying, 20 °C (HV) |
mp | 244-247 °C |
249-252 °C (lit.) | |
SMILES string | Cl[H].Cl[H].NCCc1c[nH]cn1 |
solubility | H2O: 0.1 g/mL, clear, colorless |
Biochem/physiol Actions: | Histamine dihydrochloride has been shown to activate nitric oxide synthetase and suppress or inhibit the generation of reactive oxygen species (ROS). Inhibition of ROS by histamine dihydrochloride allows activation of T cells and NK cells by IL-2. In a rat model, histamine dihydrochloride suppressed ROS generated by Kupffer cells through the H2 histamine receptor. |
General description: | Histamine is a hydrophilic amine derived from the decarboxylation of histidine by the enzyme L-histidine decarboxylase. Histamine has been shown to play a role in many physiological processes such as gastric secretion, neurotransmission, immune response, vasodialation, and inflammation. Additionally, studies have reported a role for histamine dihydrochloride with interleukin-2 (IL-2) in treatment of acute myeloid leukemia and in protection against alcohol-induced liver injury in rats. |
Other Notes: | Substrate for the assay of histamine-N-methyltransfe |
Packaging: | 1, 5, 25 g in glass bottle |
Symbol | GHS07,GHS08 |
Signal word | Danger |
Hazard statements | H315 - H317 - H319 - H334 - H335 |
Precautionary statements | P280 - P302 + P352 - P305 + P351 + P338 |
Hazard Codes | Xn |
Risk Statements | 36/37/38-42/43 |
Safety Statements | 22-26-36/37/39-45 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 2 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥99.0% (AT) |
mp | 244-247 °C; 249-252 °C (lit.) |
UNSPSC | 12352116 |