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FITC-CM-Dextran

SIGMA/53471 - average mol wt 70,000

Synonym: FITC-CM-Dextran 70; Fluorescein isothiocyanate–Carboxymethyl–Dextran

Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-53471-1G 1 g
$637.00
1/EA
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composition carboxymethyl content, 3-7%
conjugate FITC conjugate
extent of labeling 0.001-0.020 mol/mol FITC glucose
fluorescence λex 493 nm; λem 517 nm±5 nm in 0.1 M Tris pH 8.0
form powder or crystals
mol wt average mol wt 70,000
Quality Level 100 
technique(s) permeability assay: suitable
Application: FITC-CM-dextran is used to study drug intake and delivery mechanisms in HeLa cell lines. FITC-CM-Dextran was chosen due to its high water solubility and negative charge. It is also a suitable molecule to be used in encapsulation studies for polymersomal drug delivery systems or Ps DDS. FITC-CM-Dextran is a biocompatible molecule used as a starting material in several pharmaceutical and diagnostic applications.
General description: FITC-CM-Dextran, also known as Fluorescein isothiocyanate–Carboxymethyl–Dextran, is an anionic fluorescent probe. The carboxyl group provides the negative charge, which improves the overall permeability of the molecule. It is supplied as a yellow powder that is freely soluble in water and electrolyte solutions. FITC-CM-Dextran is insoluble in most organic samples such as ethanol, methanol, acetone, and chloroform. FITC-CM-Dextran is manufactured by reacting selected dextran fractions with an activated carboxymethyl derivative in alkali, whereby O-carboxymethyl groups are introduced along the dextran chain.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
UNSPSC 12352200

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