Hyaluronic acid sodium salt from Streptococcus equi

SIGMA/53747 - bacterial glycosaminoglycan polysaccharide

Synonym: Poly(β-glucuronic acid-[1→3]-β-N-acetylglucosamine-[1→4]), alternating

CAS Number: 9067-32-7
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-53747-1G	1 g	$101.00 1/EA		Add To Favorites
45-53747-10G	10 g	$524.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

biological source	(Streptococcus equi)
color	white
form	powder or crystals
impurities	≤1% protein
InChI	1S/C28H44N2O23.Na/c1-5(33)29-9-18(11(35)7(3-31)47-25(9)46)49-28-17(41)15(39)20(22(53-28)24(44)45)51-26-10(30-6(2)34)19(12(36)8(4-32)48-26)50-27-16(40)13(37)14(38)21(52-27)23(42)43;/h7-22,25-28,31-32,35-41,46H,3-4H2,1-2H3,(H,29,33)(H,30,34)(H,42,43)(H,44,45);/q;+1/t7-,8-,9-,10-,11-,12-,13+,14+,15-,16-,17-,18-,19-,20+,21+,22+,25-,26+,27-,28-;/m1./s1
InChI key	YWIVKILSMZOHHF-QJZPQSOGSA-N
mol wt	~1.5-1.8 x 10E6 Da
Quality Level	200
SMILES string	[Na+].CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2C([O-])=O
solubility	H₂O: 5 mg/mL, clear, colorless
storage temp.	−20°C

Application:	Hyaluronic acid sodium salt from Streptococcus equi has been used: • with methacrylic anhydride for synthesizing cross-linkable methacrylated HA hydrogel (Coll-MeHA) • in phosphate buffer saline (PBS) to replace the PBS bath to vary the lubricant composition • in the preparation of lubricant to study its effects on the boundary lubrication of human osteoarthritis (OA) cartilage
Biochem/physiol Actions:	Hyaluronic acid (HA), an important component of synovial fluid and articular cartilage serves as the boundary lubricant. It exhibits several physicochemical properties including biodegradability, biocompatibility, nontoxicity, and nonimmunogenicity. HA is considered a great tool for biomedical uses like drug delivery, tissue engineering, plastic surgery, ocular surgery, and osteoarthritis surgery. It participates in cushioning and lubricating the body. This powerful antioxidant can bond water to tissue.
General description:	Hyaluronic acid (HA), a vital component of the extracellular matrix in the central nervous system, is the versatile macromolecule found in the connective tissues of all vertebrates. This supramolecular glycosaminoglycan is a polyanionic natural polymer occurring as a linear polysaccharide. It is made up of glucuronic acid and N-acetylglucosamine repeats through a β-1,4 linkage. HA is seen abundantly in the eyes, joints, and heart valves.
Other Notes:	To gain a comprehensive understanding of our extensive range of Polysaccharides for your research, we encourage you to visit our Carbohydrates Category page.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	−20°C
UNSPSC	51202002

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