Tn Antigen
SIGMA/53886 - ≥99.0% (TLC)
Synonym: GalNac-α-1-O-serine; O-
CAS Number: 67262-86-6
Empirical Formula (Hill Notation): C11H20N2O8
Molecular Weight: 308.29
MDL Number: MFCD01863462
Linear Formula: C11H20N2O8
Product Type: Chemical
assay | ≥99.0% (TLC) |
form | powder or crystals |
InChI | 1S/C11H20N2O8/c1-4(15)13- |
InChI key | REDMNGDGDYFZRE-WKWISIMFSA |
Quality Level | 100 |
SMILES string | CC(=O)N[C@@H]1[C@@H](O)[C |
storage temp. | −20°C |
Biochem/physiol Actions: | Tn antigen stimulates colorectal cancer metastasis through the activation of epithelial-mesenchymal transition, mediated by H-Ras. It acts as a precursor to several significant complex O-glycans. Subpopulations of blood cells in all lineages carrying the Tn antigen results in a hematological disorder called Tn syndrome. |
General description: | Tn antigen is a truncated O-glycan, that is commonly noticed in colorectal cancer (CRC). It is usually expressed at high levels in cancer cells. Tn antigen is small in size and simple in structure. It has a non-physiological glycan structure in humans, hence it may be identified as foreign by the immune system. |
Packaging: | Bottomless glass bottle. Contents are inside inserted fused cone. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥99.0% (TLC) |
Storage Temp. | −20°C |
UNSPSC | 12352204 |