Digoxigenin NHS-ester

SIGMA/55865 - ≥80% (HPLC)

Synonym: ε-(Digoxigenin-3-0-acetamido)caproic acid N-hydroxysuccinimide ester; DIG NHS

CAS Number: 129273-26-3
Empirical Formula (Hill Notation): C₃₅H₅₀N₂O₁₀
Molecular Weight: 658.78
MDL Number: MFCD02093394
Linear Formula: C₃₅H₅₀N₂O₁₀
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-55865-1MG-F	1 mg	$307.00 1/EA	Add To Favorites
45-55865-5MG-F	5 mg	$1090.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥80% (HPLC)
form	solid
InChI	1S/C35H50N2O10/c1-33-13-11-23(45-20-28(39)36-15-5-3-4-6-31(42)47-37-29(40)9-10-30(37)41)17-22(33)7-8-25-26(33)18-27(38)34(2)24(12-14-35(25,34)44)21-16-32(43)46-19-21/h16,22-27,38,44H,3-15,17-20H2,1-2H3,(H,36,39)/t22-,23+,24-,25-,26+,27-,33+,34+,35+/m1/s1
InChI key	KHNDABJZSPPYLE-FUGFVFQCSA-N
Quality Level	200
shipped in	wet ice
SMILES string	[H][C@]12CC[C@]3([H])[C@]([H])(C[C@@H](O)[C@]4(C)[C@H](CC[C@]34O)C5=CC(=O)OC5)[C@@]1(C)CC[C@@H](C2)OCC(=O)NCCCCCC(=O)ON6C(=O)CCC6=O
storage temp.	−20°C

Application:	Digoxigenin NHS-ester has been used in the preparation of streptavidin-digoxigenin conjugate and digoxin-recombinant Ara h1 (peanut component) conjugate for enzyme-linked immunosorbent assay (ELISA) analysis.
Biochem/physiol Actions:	Digoxigenin NHS-ester is an activated ester that reacts with amino groups under mild conditions, attaching the digoxigenin moiety to proteins or 5′-amino substituted oligonucleotides Digoxigenin labeling is used to immuno-tag molecules for detection using anti-digoxigenin antibodies with high affinities and specificity.
Biochem/physiol Actions:	Digoxigenin, an aglycon, is a pharmacologically active plant toxin. It is less potent than digoxin. It is used in lower doses to treat heart conditions. Digoxigenin is usually conjugated to another payload which reduces its remaining activity or accessibility to tissues. Since digoxigenin is permanently bound and entirely covered by the capture modules, it cannot be used as an active entity.

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H300 + H310 + H330 - H373
Precautionary statements	P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310 - P314
Hazard Codes	T+
Risk Statements	26/27/28-33
Safety Statements	28-36/37-45
RIDADR	UN 2811 6.1 / PGII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥80% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352108

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