Hypericin from Hypericum perforatum
SIGMA/56690 - ~95% (HPLC)
Synonym: 4,5,7,4′,5′,7′-Hexahydroxy-2,2′-dimethylnaphthodianthrone; Cyclo werrol; Hypericum red
CAS Number: 548-04-9
Empirical Formula (Hill Notation): C30H16O8
Molecular Weight: 504.44
EC Number: 208-941-0
MDL Number: MFCD00016683
Linear Formula: C30H16O8
Product Type: Chemical
| assay | ~95% (HPLC) |
| InChI | 1S/C30H16O8/c1-7-3-9(31)1 |
| InChI key | BTXNYTINYBABQR-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Cc1cc(O)c2C(=O)c3c(O)cc(O |
| solubility | 1 M NaOH: 10 mg/mL, turbid, dark green |
| Application: | Hypericin from Hypericum perforatum has been used: • in the broth macrodilution test and antibacterial assay against bacterial strains • as a medium supplement for human malignant melanoma cells for irradiation and localization studies • as a ligand for pregnane X receptor (PXR) and as defatting medium supplement for primary human hepatocytes culture |
| Biochem/physiol Actions: | Anthraquinone-derivative within St. John′s wort. Antibacterial effective against Gram-positive and Gram-negative bacteria. |
| Biochem/physiol Actions: | Hypericin is a potent inhibitor of protein kinase C (PKC), telomerase, cytochrome P450 and reverse transcriptase. It is exploited for its photosensitizing functionality in photodynamic therapy (PDT) and photodynamic diagnosis (PDD) in cancer cells. |
| General description: | Hypericin hydrophobic is a red color pigment occurring naturally in Hypericum perforatum. Its fluorescence is measured at 600 nm. It is localized in the intracellular membranes including nuclear membrane, mitochondrial membrane, Golgi apparatus, lysosomes and endoplasmic reticulum. |
| Packaging: | Bottomless glass bottle. Contents are inside inserted fused cone. |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301 + P312 + P330 |
| Hazard Codes | Xn |
| Risk Statements | 22-43 |
| Safety Statements | 36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ~95% (HPLC) |
| UNSPSC | 12352202 |