Indole-3-propionic acid

SIGMA/57400 - ≥99.0% (T)

Synonym: 3-(3-Indolyl)propanoic acid; 3-(3-Indolyl)propionic acid; IPA; NSC 3252; NSC 47831

CAS Number: 830-96-6
Empirical Formula (Hill Notation): C₁₁H₁₁NO₂
Molecular Weight: 189.21
EC Number: 212-600-1
MDL Number: MFCD00005660
Linear Formula: C₁₁H₁₁NO₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-57400-5G-F	5 g	$109.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥99.0% (T)
form	solid
ign. residue	≤0.1%
InChI	1S/C11H11NO2/c13-11(14)6-5-8-7-12-10-4-2-1-3-9(8)10/h1-4,7,12H,5-6H2,(H,13,14)
InChI key	GOLXRNDWAUTYKT-UHFFFAOYSA-N
mp	~133 °C
Quality Level	200
SMILES string	OC(=O)CCc1c[nH]c2ccccc12

Application:

Elucidating the Interaction of Indole-3-Propionic Acid and Calf Thymus DNA: Multispectroscopic and Computational Modeling Approaches.: This study investigates the binding interaction between indole-3-propionic acid and calf thymus DNA, employing multispectroscopic techniques and computational modeling. The insights gained could lead to a deeper understanding of the molecular mechanisms underpinning the protective effects of this compound on DNA integrity, critical for developing novel therapeutic strategies in biochemistry (Wei Y et al., 2024 ).

The Tryptophan Metabolite Indole-3-Propionic Acid Raises Kynurenic Acid Levels in the Rat Brain In Vivo.: This research demonstrates how indole-3-propionic acid, a metabolite of tryptophan, can increase levels of kynurenic acid in the brain, offering potential benefits in neuroprotective strategies and the study of psychiatric disorders. Such findings highlight significant implications for mental health research and therapeutic applications (Sathyasaikumar KV et al., 2024 ).

Serum-Derived Bovine Immunoglobulin Promotes Barrier Integrity and Lowers Inflammation for 24 Human Adults Ex Vivo.: This study explores how indole-3-propionic acid impacts inflammatory responses and gut barrier integrity, providing valuable data for nutritional science and clinical applications aimed at reducing gastrointestinal disorders and enhancing overall gut health (Van den Abbeele P et al., 2024 ).

The Effect of Type 2 Resistant Starch and Indole-3-Propionic Acid on Ameliorating High-Fat-Diet-Induced Hepatic Steatosis and Gut Dysbiosis.: This publication discusses the beneficial effects of indole-3-propionic acid in conjunction with type 2 resistant starch on reducing hepatic steatosis and correcting gut dysbiosis caused by high-fat diets, pointing to potential dietary interventions for managing obesity and associated metabolic disorders (Yang M et al., 2024 ).

Gut microbiome and cardiometabolic comorbidities in people living with HIV.: This review highlights the role of indole-3-propionic acid in modulating the gut microbiome and its potential effects on cardiometabolic health in HIV-positive individuals. The findings suggest a promising avenue for improving the quality of life and health outcomes in this population through microbiome-based interventions (Trøseid M et al., 2024 ).

Biochem/physiol Actions:

Studied as an adjunct to improve perfusion after liver transplant.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99.0% (T)
mp	~133 °C
UNSPSC	12352106

To Order From a Quote