D-α-Tocopherol polyethylene glycol 1000 succinate
SIGMA/57668 - BioXtra, water soluble vitamin E conjugate
Synonym: D-α-Tocopherol polyethylene glycol succinate; TPGS; Vitamin E polyethylene glycol succinate; Vitamin E-TPGS
CAS Number: 9002-96-4
MDL Number: MFCD00146616
Product Type: Chemical
| biological source | synthetic |
| cation traces | Al: ≤5 mg/kg |
| Ba: ≤5 mg/kg | |
| Bi: ≤5 mg/kg | |
| Ca: ≤5 mg/kg | |
| Cd: ≤5 mg/kg | |
| Co: ≤5 mg/kg | |
| Cr: ≤5 mg/kg | |
| Cu: ≤5 mg/kg | |
| Fe: ≤5 mg/kg | |
| K: ≤50 mg/kg | |
| Li: ≤5 mg/kg | |
| Mg: ≤5 mg/kg | |
| Mn: ≤5 mg/kg | |
| Mo: ≤5 mg/kg | |
| Na: ≤50 mg/kg | |
| Ni: ≤5 mg/kg | |
| Pb: ≤5 mg/kg | |
| Sr: ≤5 mg/kg | |
| Zn: ≤5 mg/kg | |
| color | white to light brown |
| composition | α-tocopherol, ≥25% |
| concentration | ≥25% (ALPHA TOCOPHEROL) |
| form | powder, crystals or chunks |
| InChI | 1S/C35H58O6/c1-24(2)12-9- |
| InChI key | AOBORMOPSGHCAX-UHFFFAOYSA |
| mp | >36 °C |
| product line | BioXtra |
| Quality Level | 200  |
| SMILES string | CC1=C(C(=C(C2=C1OC(CC2)(C |
| solubility | H2O: 1 g/10 mL, clear to faintly turbid, colorless to faintly yellow |
| storage temp. | 2-8°C |
| Application: | |
| Application: | D-α-Tocopherol polyethylene glycol 1000 is a versatile compound that finds application in cell biology, metabolomics, biochemical and drug delivery research. |
| Biochem/physiol Actions: | |
| Biochem/physiol Actions: | Tocopherols (TCP) (vitamin E) are a series (α, α, α and α) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Tocopherol polyethylene glycol 1000 succinate (TPGS) may be used to create biodegradable polymers and antioxidant surfactants. TPGS exerts anti-tumor activity in MCF-7 and breast cancer cells by downregulating anti-apoptotic proteins. TPGS finds its application as an emulsifier in the preparation of poly(lactic-co-glycolic acid) (PLGA) particles for DNA labelling, produces particles of uniform size, high encapsulation efficiency, increases hydrophilicity and prevents aggregation of particles. |
| Features and Benefits: | • Can be used in Metabolomics and Biochemical research • High-quality compound suitable for multiple research applications |
| General description: | Tocofersolan, also known as Vitamin E-TPGS, is a nonionic surfactant and a synthetic polyethylene glycol derivative of α-tocopherol, commonly known as vitamin E. This water-soluble amphipathic formulation consists of d-alpha-tocopherol succinate coupled to polyethylene glycol (PEG) 1000 through a succinate linker. Its amphipathic nature enables the formation of micelles, facilitating uptake into enterocytes, even in the absence of bile salts. Upon hydrolysis, fat-soluble d-alpha-tocopherol is released. Tocofersolan significantly improves the absorption of d-alpha-tocopherol compared to free administration. Moreover, Tocofersolan acts as an inhibitor of P-glycoprotein (P-gp or MDR1) substrate-induced ATPase activity in cell-free assays. It has demonstrated efficacy against resistant K562 cells by binding to urokinase-type plasminogen activator, a crucial enzyme for cancer cell migration and invasion. Additionally, Tocofersolan inhibits tyrosine kinase, a key player in cancer cell development, offering potential applications in metabolomics and biochemical research. Its ability to enhance the absorption of water-insoluble agents and other fat-soluble vitamins positions it as a promising compound for formulation and drug delivery research. |
| Other Notes: | For additional information on our range of Biochemicals , please complete this form . |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | 392.0 °F |
| Flash Point(C) | > 200 °C |
| mp | >36 °C |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352205 |