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L-α-Lysophosphatidylcholine

SIGMA/62962 - egg yolk, ≥99.0% (TLC)

Synonym: 3-sn-Lysophosphatidylcholine; L-α-Lysolecithin

MDL Number: MFCD00131444
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-62962-250MG 250 mg
 No Price  
45-62962-1G 1 g
 No Price  
assay ≥99.0% (TLC)
biological source egg yolk
composition 16:0, ~69% (fatty acid)
  18:0, ~27% (fatty acid)
  18:1, ~3% (fatty acid)
description zwitterionic
form powder or solid
functional group phospholipid
lipid type phosphoglycerides
shipped in wet ice
solubility chloroform/methanol: 50 mg/mL, clear, colorless to very faintly yellow
storage temp. −20°C
Application:

  • The activation mode of the mechanosensitive ion channel, MscL, by lysophosphatidylcholine differs from tension-induced gating: L-α-LPC is explored for its unique interaction with ion channels, suggesting its potential as a tool for studying channel mechanics and developing new therapeutic strategies for diseases linked to cellular mechanics (Mukherjee et al., 2014 ).

  • Aerosol delivery of an enhanced helper-dependent adenovirus formulation to rabbit lung using an intratracheal catheter: The use of L-α-LPC in enhancing the delivery of gene therapy vectors via aerosol demonstrates its utility in improving the efficiency of gene therapies, particularly for respiratory diseases (Koehler et al., 2005 ).
Biochem/physiol Actions: 3-sn-Lysophosphatidylcholine, besides contributing to the positive curvature of membranes , inhibits SNARE complex disassembly in vitro and in rat nerve terminals and exocrine pancrease .
Other Notes: Preparation of demembranated frog sperm chromatin
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥99.0% (TLC)
Storage Temp. −20°C
UNSPSC 51321705

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