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2,3-Naphthalenedicarboxaldehyde

SIGMA/70215 - suitable for fluorescence

Synonym: NDA

CAS Number: 7149-49-7
Empirical Formula (Hill Notation): C12H8O2
Molecular Weight: 184.19
MDL Number: MFCD00016618
Linear Formula: C10H6(CHO)2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-70215-100MG 100 mg
 $230.00
1/EA		 Add To Favorites
45-70215-500MG 500 mg
 $854.00
1/EA		 Add To Favorites

 

fluorescence λex 420 nm; λem ~480 nm in 0.1 M borate pH 9.3 (after derivatization with glycine [~90 μM glycine, ~20 μM N-])
form crystals
impurities ≤2% mono- and dicarboxylic acid (1H-NMR)
InChI 1S/C12H8O2/c13-7-11-5-9-3-1-2-4-10(9)6-12(11)8-14/h1-8H
InChI key ZIPLKLQPLOWLTM-UHFFFAOYSA-N
mp 131-133 °C (lit.)
  132-135 °C
Quality Level 100 
SMILES string [H]C(=O)c1cc2ccccc2cc1C([H])=O
storage temp. 2-8°C
suitability suitable for fluorescence
Application: 2,3-Naphthalenedicarboxaldehyde is used as a fluorescent labelling agent for quantification of Histamine in human immunoglobulin preparations. NAD is used as a derivatization agent for glutathione to quantify protein glutathionylation. It is a suitable reagent used for the development of fluorescence-based microtiter plate assay for γ-glutamylcyclotransferase.
Features and Benefits: NDA based fluorescent assays have the following benefits over O-Phthalaldehyde (OPA):

• High Reaction rate.
• High Fluorescence quantum yield.
• No uncommon excitation wavelength.
• No side reactions.
General description: 2,3-Naphthalenedicarboxaldehyde, also known as NDA, is a novel fluorescent derivatization agent. The fluorescence max. excitation of NDA is in the range of 424 nm and max. emission is achieved at 484nm.

2,3-Naphthalenedicarboxaldehyde is a fluorescent derivatization agent of primary amines, amino acids, and small peptides. The reaction between the amino compounds and NDA results in highly fluorescent and stable derivative compounds.
Packaging: 100 mg in poly bottle
Packaging: 500 mg in poly tube
mp 131-133 °C (lit.); 132-135 °C
Storage Temp. 2-8°C
UNSPSC 12352108

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