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Sphingosine 1-phosphate

SIGMA/73914 - ≥98.0% (TLC)

Synonym: (2S,3R,4E)-2-Amino-4-octadecene-1,3-diol 1-phosphate; D-erythro-Sphingosine 1-phosphate

CAS Number: 26993-30-6
Empirical Formula (Hill Notation): C18H38NO5P
Molecular Weight: 379.47
MDL Number: MFCD00270077
Linear Formula: C18H38NO5P
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-73914-1MG 1 mg
 $350.00
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45-73914-5MG 5 mg
 $1290.00
1/EA		 Add To Favorites

 

assay ≥98.0% (TLC)
composition carbon content, 56.97%
  hydrogen content, 10.09%
  nitrogen content, 3.69%
form powder
InChI 1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
InChI key DUYSYHSSBDVJSM-KRWOKUGFSA-N
lipid type sphingolipids
Quality Level 100 
SMILES string CCCCCCCCCCCCCC=C[C@@H](O)[C@@H](N)COP(O)(O)=O
storage temp. −20°C
Application: Repurposing Siponimod for osteoporosis: A study highlighted the potential of Siponimod, an S1P receptor modulator originally developed for multiple sclerosis, to treat osteoporosis by influencing Sphingosine 1-phosphate pathways (Hu et al., 2024). 

Sphingosine-1-phosphate in ocular health: Research demonstrated that a selective agonist for Sphingosine-1-phosphate receptor 1/5 could mitigate ocular vascular pathologies, suggesting therapeutic potentials in eye disease management, it is also responsible for regulating various intracellular processes, including cell survival, differentiation, and proliferation (Nakamura et al., 2024). 

Targeting diabetic kidney disease: The study investigated how Plantaginis Semen, through the sphingosine kinase 1/Sphingosine-1-phosphate pathway, could ameliorate diabetic kidney disease, underscoring the pathways role in metabolic health (Lan et al., 2024). 

Advancements in neurodegenerative disease treatments: A review focused on the development of small-molecule modulators targeting Sphingosine-1-phosphate receptors, presenting new directions in treating neurodegenerative diseases (Sankar Kar et al., 2024). 
Biochem/physiol Actions: A lipid second messenger that binds to S1P1 and S1P3 receptors. Mobilizes intracellular Ca2+ stores and decreases cellular cAMP. Activates phospholipase D. S1P stimulates the migration of endothelial cells but inhibits the migration of other cell types. Induces angiogenesis.
Packaging: Bottomless glass bottle. Contents are inside inserted fused cone.
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98.0% (TLC)
Storage Temp. −20°C
UNSPSC 12352211

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