Nourseothricin sulfate
SIGMA/74667 - ≥85% (HPLC)
CAS Number: 96736-11-7
MDL Number: MFCD00165013
Product Type: Chemical
| antibiotic activity spectrum | fungi |
| Gram-negative bacteria | |
| Gram-positive bacteria | |
| mycobacteria | |
| mycoplasma | |
| parasites | |
| viruses | |
| yeast | |
| assay | ≥85% (HPLC) |
| biological source | Streptomyces noursei |
| color | white to light brown |
| form | solid |
| mode of action | protein synthesis | interferes |
| Quality Level | 100  |
| solubility | H2O: soluble 200 mg/mL |
| storage temp. | 2-8°C |
| suitability | suitable for (selection agent for molecular genetic research work) |
| Application: | Noursethricin is used as a dominant selection antibiotic for genetically modified bacteria, yeasts, fungi, protozoa and plants. |
| Biochem/physiol Actions: | Antifungal effective against Candida albicans. Candida species transformed with the gene encoding nourseothricin acetyltransferase (CaNAT1) were resistant to nourseothricin. |
| Biochem/physiol Actions: | Nourseothricin inhibits biosynthesis and induces miscoding. Resistance to nourseothricin is mediated by the sat1 encoded N-acetyltransferase. Nourseothricin is inactivated by acetylation of the β-amino group of the β-lysin. |
| General description: | Chemical structure: peptidyl nucleoside |
| Other Notes: | Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. |
| Packaging: | 10mg, 100mg |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Precautionary statements | P301 + P312 + P330 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥85% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 51101500 |