Nourseothricin sulfate

SIGMA/74667 - ≥85% (HPLC)

CAS Number: 96736-11-7
MDL Number: MFCD00165013
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-74667-10MG	10 mg	$333.00 1/EA		Add To Favorites
45-74667-100MG	100 mg	$2390.00 1/EA		Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	fungi
	Gram-negative bacteria
	Gram-positive bacteria
	mycobacteria
	mycoplasma
	parasites
	viruses
	yeast
assay	≥85% (HPLC)
biological source	Streptomyces noursei
color	white to light brown
form	solid
InChI key	HEPYPTBGGNPPAP-SPCBHCMPSA-N
mode of action	protein synthesis \| interferes
Quality Level	100
SMILES string	[S](=O)(=O)(O)O.N4[C@H]5[C@H](N=C4N[C@@H]6O[C@@H]([C@@H]([C@H]([C@H]6NC(=O)C[C@@H](N)CCCNC(=O)C[C@@H](N)CCCNC(=O)C[C@@H](N)CCCN)O)OC(=O)N)CO)C(=O)NC[C@H]5O.N1[C@H]2[C@H](N=C1N[C@@H]3O[C@@H]([C@@H]([C@H]([C@H]3NC(=O)C[C@@H](N)CCCN)O)OC(=O)N)CO)C(=O)NC[C@H]
solubility	H₂O: soluble 200 mg/mL
storage temp.	2-8°C
suitability	suitable for (selection agent for molecular genetic research work)

Application:	Noursethricin is used as a dominant selection antibiotic for genetically modified bacteria, yeasts, fungi, protozoa and plants.
Biochem/physiol Actions:	Antifungal effective against Candida albicans. Candida species transformed with the gene encoding nourseothricin acetyltransferase (CaNAT1) were resistant to nourseothricin.
Biochem/physiol Actions:	Nourseothricin inhibits biosynthesis and induces miscoding. Resistance to nourseothricin is mediated by the sat1 encoded N-acetyltransferase. Nourseothricin is inactivated by acetylation of the β-amino group of the β-lysin.
General description:	Chemical structure: peptidyl nucleoside
Other Notes:	Keep container tightly closed in a dry and well-ventilated place. Store under inert gas.
Packaging:	10mg, 100mg

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P301 + P312 + P330
Hazard Codes	Xn
Risk Statements	22-36/37/38
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥85% (HPLC)
Storage Temp.	2-8°C
UNSPSC	51102829

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