Synonym: (R)-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide; (R)-2,4-Dihydroxy-3,3-dimethylbutyric 3-hydroxypropylamide; D-Pantothenyl alcohol; Dexpanthenol; Provitamin B
CAS Number: 81-13-0
Empirical Formula (Hill Notation): C9H19NO4
Molecular Weight: 205.25
EC Number: 201-327-3
MDL Number: MFCD00065006
Linear Formula: C9H19NO4
Product Type: Chemical
| assay |
≥98.0% (NT) |
| biological source |
synthetic |
| color |
colorless |
| density |
1.20 g/mL at 20 °C (lit.) |
| form |
liquid |
| ign. residue |
≤0.1% (as SO4) |
| impurities |
≤0.002% heavy metals |
| |
≤0.5% 3-aminopropanol |
| InChI |
1S/C9H19NO4/c1-9(2,6-12)7(13)8(14)10-4-3-5-11/h7,11-13H,3-6H2,1-2H3,(H,10,14)/t7-/m0/s1 |
| InChI key |
SNPLKNRPJHDVJA-ZETCQYMHSA-N |
| optical activity |
[α]20/D +30±1°, c = 5% in H2O |
| Quality Level |
200  |
| refractive index |
n20/D 1.496-1.500 |
| SMILES string |
CC(C)(CO)[C@@H](O)C(=O)NCCCO |
| storage temp. |
2-8°C |
| Application: |
- The combination of allantoin, bisabolol, D-panthenol and dipotassium glycyrrhizinate mitigates UVB-induced PGE(2) synthesis by keratinocytes.: This study investigates the protective effects of D-panthenol, combined with other compounds, against UVB-induced inflammation in keratinocytes. The results highlight D-panthenol′s role in skin care formulations aimed at reducing UV-induced damage and inflammation (Tan et al., 2024
 ).
- Protective Effect of D-Panthenol in Rhabdomyolysis-Induced Acute Kidney Injury.: This research explores the protective properties of D-panthenol in mitigating acute kidney injury caused by rhabdomyolysis. The findings suggest potential therapeutic applications for D-panthenol in renal protection and recovery (Semenovich et al., 2022 ).
- Alpha-Glycerylphosphorylcholine and D-Panthenol Eye Drops in Patients Undergoing Cataract Surgery.: This clinical study examines the efficacy of eye drops containing D-panthenol in patients undergoing cataract surgery, demonstrating its potential to enhance postoperative recovery and eye health (Martone et al., 2022 ).
- Common Cosmetic Compounds Can Reduce Air Pollution-Induced Oxidative Stress and Pro-Inflammatory Response in the Skin.: This study highlights the role of D-panthenol in protecting the skin against oxidative stress and inflammation caused by air pollution, emphasizing its importance in cosmetic formulations for urban environments (Hergesell et al., 2022 ).
|
| Biochem/physiol Actions: |
D-Panthenol is the alcohol analogue and biological precursor of D-pantothenic acid. These analogues are precursors in the biosynthesis of coenzyme A. D-Panthenol and D-Pantothenic acid are used in a variety of skin protection products. D-pantothenic acid may have a role in controlling keratinocyte proliferation and differentiation. D-Panthenol may be used for studies of skin protection emulsions from UV irradiation and as a humectant. |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 1 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98.0% (NT) |
| Density |
1.20 g/mL at 20 °C (lit.) |
| Refractive Index |
n20/D 1.496-1.500 |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352104 |
