Liquiritigenin

SIGMA/78825 - ≥97.0% (HPLC)

Synonym: 7,4′-Dihydroxyflavanone; 7-Hydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-1-benzopyran-4-one

Empirical Formula (Hill Notation): C₁₅H₁₂O₄
Molecular Weight: 256.25
MDL Number: MFCD00287289
Linear Formula: C₁₅H₁₂O₄
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-78825-10MG	10 mg	$281.00 1/EA		Add To Favorites
45-78825-50MG	50 mg	$745.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

application(s)	metabolomics vitamins, nutraceuticals, and natural products
assay	≥97.0% (HPLC)
form	powder or crystals
impurities	≤7% water
InChI	1S/C15H12O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-7,14,16-17H,8H2/t14-/m0/s1
InChI key	FURUXTVZLHCCNA-AWEZNQCLSA-N
Quality Level	100
SMILES string	Oc1ccc(cc1)[C@@H]2CC(=O)c3ccc(O)cc3O2

Application:	Liquiritigenin has been used: • to study its inhibitory effect on tumor metastasis in the treatment of colorectal cancer • as a reference standard for ultra-performance liquid chromatography (UPLC) of Chaihu-Shugan-San (CSS) extract • as a potential antiviral drug against hepatitis C virus (HCV) infection
Biochem/physiol Actions:	Liquiritigenin displays anti-diabetic and choleretic properties. It exerts anti-inflammatory activity on Raw246.7 cells by inhibiting nuclear factor kappa light chain enhancer of activated B cells (NF-κB)-dependent-induction of inducible NOS (iNOS). Liquiritigenin inhibits liver fibrogenesis by blocking Hippo/Yes-associated protein (YAP) and transforming growth factor-β1 (TGF-β1)/small mothers against decapentaplegic (Smad) components. It is a selective estrogen receptor β agonist cells. Liquiritigenin induces apoptosis in SMM-721 cells by disruption of the mitochondrial membrane potential and increased production of reactive oxygen species.
General description:	Liquiritigenin is a flavonoid and an estrogenic compound found in licorice (Glycyrrhizae radix) root extract and several other plants.
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97.0% (HPLC)
UNSPSC	12352202

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