Pyridoxal 5′-phosphate monohydrate
SIGMA/82870 - ≥97.0% (NT)
Synonym: P5P; 3-
CAS Number: 41468-25-1
Empirical Formula (Hill Notation): C8H10NO6P · H2O
Molecular Weight: 265.16
MDL Number: MFCD00149414
Linear Formula: C8H10NO6P · H2O
Product Type: Chemical
| anion traces | chloride (Cl-): ≤500 mg/kg |
| sulfate (SO42-): ≤50 mg/kg | |
| application(s) | cell analysis |
| assay | ≥97.0% (NT) |
| biological source | synthetic |
| cation traces | Ca: ≤20 mg/kg |
| Cd: ≤5 mg/kg | |
| Co: ≤5 mg/kg | |
| Cr: ≤5 mg/kg | |
| Cu: ≤5 mg/kg | |
| Fe: ≤50 mg/kg | |
| K: ≤50 mg/kg | |
| Mg: ≤5 mg/kg | |
| Mn: ≤5 mg/kg | |
| Na: ≤2000 mg/kg | |
| Ni: ≤5 mg/kg | |
| Pb: ≤5 mg/kg | |
| Zn: ≤5 mg/kg | |
| color | white to light yellow |
| form | powder |
| InChI | 1S/C8H10NO6P.H2O/c1-5-8(1 |
| InChI key | CEEQUQSGVRRXQI-UHFFFAOYSA |
| mp | 140-143 °C (lit.) |
| Quality Level | 200  |
| SMILES string | O=CC1=C(C(C)=NC=C1COP(O)( |
| storage temp. | 2-8°C |
| technique(s) | enzyme immunoassay: suitable |
| Application: | Pyridoxal 5′-phosphate monohydrate has been used: • as a component in the reaction mixture for ornithine decarboxylase (ODC) activity assay • as a standard to quantify the concentration of pyridoxal 5′-phosphate (PLP) in cerebrospinal fluid (CSF) of children • as a dietary supplement to study its effects on the lethal phenotype of mutant flies |
| Biochem/physiol Actions: | Pyridoxine participates in the production of lipid and neurotransmitters. Pyridoxal 5′-phosphate (PLP) serves as a cofactor to stabilize carbanions at Cα of amino acids. Pyridoxine deficiency results in peripheral neuropathy. Absence of PLP leads to neonatal epileptic encephalopathy. PLP acts as a coenzyme in transamination, decarboxylation and deamination reactions such as the conversion of dopa into dopamine; of glutamate into γ aminobutyric acid (GABA); of histidine to histamine. PLP works mechanistically through formation of a Schiff-base. |
| General description: | Pyridoxal 5′-phosphate (PLP), an active form of vitamin B |
| Other Notes: | Coenzymes and Cofactors, vol. 1: Vitamin B6, Pyridoxal Phosphate |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥97.0% (NT) |
| mp | 140-143 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352204 |