Spermidine
SIGMA/85558 - BioUltra, for molecular biology, ≥99.5% (GC)
Synonym: SPD; 1,8-
CAS Number: 124-20-9
Empirical Formula (Hill Notation): C7H19N3
Molecular Weight: 145.25
EC Number: 204-689-0
MDL Number: MFCD00008229
Linear Formula: NH2(CH2)3NH(CH2)4NH2
Product Type: Chemical
| λ | 1 M in H2O |
| anion traces | chloride (Cl-): ≤50 mg/kg |
| sulfate (SO42-): ≤50 mg/kg | |
| application(s) | advanced drug delivery genomic analysis |
| assay | ≥99.5% (GC) |
| cation traces | Al: ≤5 mg/kg |
| As: ≤0.1 mg/kg | |
| Ba: ≤5 mg/kg | |
| Bi: ≤5 mg/kg | |
| Ca: ≤10 mg/kg | |
| Cd: ≤5 mg/kg | |
| Co: ≤5 mg/kg | |
| Cr: ≤5 mg/kg | |
| Cu: ≤5 mg/kg | |
| Fe: ≤5 mg/kg | |
| K: ≤50 mg/kg | |
| Li: ≤5 mg/kg | |
| Mg: ≤5 mg/kg | |
| Mn: ≤5 mg/kg | |
| Mo: ≤5 mg/kg | |
| Na: ≤50 mg/kg | |
| Ni: ≤5 mg/kg | |
| Pb: ≤5 mg/kg | |
| Sr: ≤5 mg/kg | |
| Zn: ≤5 mg/kg | |
| density | 0.925 g/mL at 25 °C (lit.) |
| grade | for molecular biology |
| impurities | DNases, none detected |
| insoluble matter, passes filter test | |
| phosphatases, none detected | |
| proteases, none detected | |
| RNases, none detected | |
| InChI | 1S/C7H19N3/c8-4-1-2-6-10- |
| InChI key | ATHGHQPFGPMSJY-UHFFFAOYSA |
| pH | 12.0-13.5 (25 °C, 1 M in H2O) |
| product line | BioUltra |
| Quality Level | 200  |
| refractive index | n |
| SMILES string | NCCCCNCCCN |
| solubility | H2O: 1 M at 20 °C, clear, colorless |
| storage condition | (Tightly closed. Keep locked up or in an area accessible only to qualified or authorizedpersons.) |
| suitability | suitable for molecular biology |
| technique(s) | buffer exchange: suitable |
| ChIP: suitable | |
| UV absorption | λ: 260 nm Amax: 0.1 |
| λ: 280 nm Amax: 0.05 |
| Analysis Note: | liquid or solid |
| Application: | Spermidine has been used: • as a component of chromosome isolation buffer • as a component of transcription buffer • as a component of homogenization buffer |
| Biochem/physiol Actions: | Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity. |
| Biochem/physiol Actions: | Spermidine modulates various cellular activities like cellular growth and development, stability of DNA and apoptosis. |
| Caution: | Solutions should be sterile-filtered, not autoclaved, if sterile solution is necessary. Spermidine deaminates with time; solutions should be stored frozen. Prepare new solutions frequently. |
| Features and Benefits: | • Versatile and adaptable for a wide variety of laboratory and research applications • Suitable for Molecular Biology and Biochemical research • Free from DNase, RNase, NICKase, and protease • Tested to confirm low levels of heavy metal contamination, ensuring suitability for various applications • Tested for trace levels of Anions and Cations |
| General description: | Spermidine is a polyamine and a trivalent organic cation.Spermidine is a naturally occurring polyamine compound with diverse biochemical properties. It plays a vital role in gene expression, participating in DNA replication, transcription, and translation processes. Spermidine is crucial for cell growth, proliferation, and differentiation, influencing cell cycle progression and tissue development. It possesses antioxidant activity, safeguarding cells against oxidative stress by scavenging free radicals. Spermidine also stimulates autophagy, promoting the turnover of damaged organelles and protein aggregates for cellular homeostasis. With neuroprotective effects, it supports neuronal survival, synaptic plasticity, and guards against neurodegenerative diseases. Additionally, spermidine modulates cellular signaling pathways involved in inflammation and immune responses. |
| Other Notes: | For additional information on our range of Biochemicals , please complete this form . |
| Other Notes: | In first strand cDNA synthesis; Effect on endonuclease inhibition by agarose contaminants |
| Symbol |  GHS05 |
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P280 - P305 + P351 + P338 - P310 |
| Hazard Codes | C |
| Risk Statements | 34 |
| Safety Statements | 26-36/37/39-45 |
| RIDADR | UN 3259PSN2 8 / PGII |
| WGK Germany | WGK 3 |
| Flash Point(F) | 233.6 °F - closed cup |
| Flash Point(C) | 112 °C - closed cup |
| Purity | ≥99.5% (GC) |
| Density | 0.925 g/mL at 25 °C (lit.) |
| Refractive Index | n |
| UNSPSC | 12352116 |