Spermine tetrahydrochloride
SIGMA/85605 - BioUltra, for molecular biology, ≥99.5% (AT)
Synonym: N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride
CAS Number: 306-67-2
Empirical Formula (Hill Notation): C10H26N4 · 4HCl
Molecular Weight: 348.18
EC Number: 206-189-8
MDL Number: MFCD00012914
Linear Formula: C10H26N4 · 4HCl
Product Type: Chemical
λ | 1 M in H2O |
anion traces | sulfate (SO42-): ≤50 mg/kg |
assay | ≥99.5% (AT) |
cation traces | Al: ≤5 mg/kg |
As: ≤0.1 mg/kg | |
Ba: ≤5 mg/kg | |
Bi: ≤5 mg/kg | |
Ca: ≤10 mg/kg | |
Cd: ≤5 mg/kg | |
Co: ≤5 mg/kg | |
Cr: ≤5 mg/kg | |
Cu: ≤5 mg/kg | |
Fe: ≤5 mg/kg | |
K: ≤50 mg/kg | |
Li: ≤5 mg/kg | |
Mg: ≤5 mg/kg | |
Mn: ≤5 mg/kg | |
Mo: ≤5 mg/kg | |
Na: ≤50 mg/kg | |
Ni: ≤5 mg/kg | |
Pb: ≤5 mg/kg | |
Sr: ≤5 mg/kg | |
Zn: ≤5 mg/kg | |
form | powder |
grade | for molecular biology |
impurities | DNases, none detected |
insoluble matter, passes filter test | |
phosphatases, none detected | |
proteases, none detected | |
RNases, none detected | |
InChI | 1S/C10H26N4.4ClH/c11-5-3- |
InChI key | XLDKUDAXZWHPFH-UHFFFAOYSA |
mp | 310-311 °C (dec.) (lit.) |
pH | 4.5-7.0 (25 °C, 1 M in H2O) |
product line | BioUltra |
Quality Level | 300 |
SMILES string | Cl.Cl.Cl.Cl.NCCCNCCCCNCCC |
solubility | H2O: 1 m at 20 °C, clear, colorless to almost colorless |
UV absorption | λ: 260 nm Amax: 0.2 |
λ: 280 nm Amax: 0.15 |
Application: | Used to precipitate DNA from low salt aqueous buffers. |
Biochem/physiol Actions: | Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS). |
Biochem/physiol Actions: | Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS). |
Other Notes: | Spermine precipitation of DNA |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H315 - H319 |
Precautionary statements | P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313 |
Hazard Codes | Xi |
Risk Statements | 36/38 |
Safety Statements | 26-36 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥99.5% (AT) |
mp | 310-311 °C (dec.) (lit.) |
UNSPSC | 12352116 |