Tetracycline
SIGMA/87128 - 98.0-102.0% (HPLC)
Synonym: Tetracycline HCL; Tetracycline Monohydrochloride
CAS Number: 60-54-8
Empirical Formula (Hill Notation): C22H24N2O8 · xH2O
Molecular Weight: 444.43 (anhydrous basis)
EC Number: 200-481-9
MDL Number: MFCD00151232
Linear Formula: C22H24N2O8 · xH2O
Product Type: Chemical
antibiotic activity spectrum | Gram-negative bacteria |
Gram-positive bacteria | |
assay | 98.0-102.0% (HPLC) |
biological source | synthetic |
color | faint yellow to dark yellow |
form | powder or crystals |
InChI | 1S/C22H24N2O8/c1-21(31)8- |
InChI key | OFVLGDICTFRJMM-WESIUVDSSA |
mode of action | protein synthesis | interferes |
mp | 172-174 °C (dec.) |
Quality Level | 200 |
SMILES string | CN(C)[C@H]1[C@@H]2C[C@H]3 |
storage temp. | 2-8°C |
Biochem/physiol Actions: | Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action. Mode of Resistance: The effects are inactivated via a loss of cell wall permeability. Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria. |
General description: | Chemical structure: tetracycline |
Other Notes: | Keep container tightly closed in a dry and well-ventilated place.Hygroscopic. Light sensitive. Keep in a dry place. |
Packaging: | 25g, 100g |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P264 - P270 - P301 + P312 - P501 |
Hazard Codes | Xn |
Risk Statements | 22 |
Safety Statements | 22-36 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | 98.0-102.0% (HPLC) |
mp | 172-174 °C (dec.) |
Storage Temp. | 2-8°C |
UNSPSC | 51101500 |