N_α-Tosyl-L-lysine chloromethyl ketone hydrochloride

SIGMA/90182 - ≥99.0% (AT)

Synonym: (3S)-1-Chloro-3-tosylamido-7-amino-2-heptanone hydrochloride; (3S)-7-Amino-1-chloro-3-tosylamino-2-heptanone hydrochloride; TLCK; Tosyl-L-lysyl-chloromethane hydrochloride

CAS Number: 4272-74-6
Empirical Formula (Hill Notation): C₁₄H₂₁ClN₂O₃S · HCl
Molecular Weight: 369.31
EC Number: 224-266-4
MDL Number: MFCD00065395
Linear Formula: C₁₄H₂₁ClN₂O₃S · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-90182-100MG	100 mg	$202.00 1/EA	Add To Favorites
45-90182-500MG	500 mg	$800.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥99.0% (AT)
biological source	synthetic
form	powder or crystals
InChI	1S/C14H21ClN2O3S.ClH/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16;/h5-8,13,17H,2-4,9-10,16H2,1H3;1H/t13-;/m0./s1
InChI key	YFCUZWYIPBUQBD-ZOWNYOTGSA-N
optical activity	[α]20/D −7.8±0.5°, c = 2% in H₂O
Quality Level	100
SMILES string	Cl[H].Cc1ccc(cc1)S(=O)(=O)N[C@@H](CCCCN)C(=O)CCl
storage temp.	−20°C

Other Notes:

An alkylating reagent that may react with histidine or cysteine residues at the active site of enzymes. Inactivates serine proteases such as trypsin and clostripain . Chymotrypsin is not affected. To prevent proteolytic degradation, a combination of TLCK and TPCK can be used throughout the isolation of proteins, as in the isolation of histones.

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥99.0% (AT)
Storage Temp.	−20°C
UNSPSC	12352202

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