Polymyxin B solution
SIGMA/92283 - 20 mg/mL in H2O
Synonym: Aerosporin; Polymyxin B; Polymyxin B Sulfate
CAS Number: 1405-20-5
MDL Number: MFCD00131991
Product Type: Chemical
antibiotic activity spectrum | fungi |
Gram-negative bacteria | |
Gram-positive bacteria | |
biological source | Bacillus polymyxa (fermentation) |
color | colorless to slightly yellow |
concentration | 20 mg/mL in H2O |
form | liquid |
InChI | 1S/C48H82N16O13.H2O4S/c1- |
InChI key | HNDFYNOVSOOGDU-UHFFFAOYSA |
mode of action | cell membrane | interferes |
optical activity | [α]/D 20/D (Rotation: -2.3 +/- 0.2 degrees) |
Quality Level | 200 |
solubility | H2O: soluble 20 mg/mL |
storage temp. | 2-8°C |
Application: | Polymyxin B is used to study multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots. |
Biochem/physiol Actions: | Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane. Mode of Resistance: The activity of Polymyxin B sulfate is inhibited by iron(II), Co(II), Mn(II) and Magnesium ions. Polymyxin B may also be incompaitible with other microbial agents, including amphoterecin, cephalothin sodium, cephasolin sodium and heparin sodium. Antimicrobial Spectrum: Has bactericidal action on most gram-negative bacilli, including E. Coli and on most fungi and gram-positive bacteria. |
General description: | Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa. |
Other Notes: | Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Handle and store under inert gas. |
Packaging: | 10ml, 125ml |
Preparation Note: | This product is concentrated at 20 mg/mL in water, and should be stored at 2-8°C. |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 2 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Storage Temp. | 2-8°C |
UNSPSC | 51101500 |