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Polymyxin B solution

SIGMA/92283 - 20 mg/mL in H2O

Synonym: Aerosporin; Polymyxin B; Polymyxin B Sulfate

CAS Number: 1405-20-5
MDL Number: MFCD00131991
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-92283-10ML 10 mL
$425.00
1/EA
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45-92283-125ML 125 mL
$4950.00
1/EA
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antibiotic activity spectrum fungi
  Gram-negative bacteria
  Gram-positive bacteria
biological source Bacillus polymyxa (fermentation)
color colorless to slightly yellow
concentration 20 mg/mL in H2O
form liquid
InChI 1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
InChI key HNDFYNOVSOOGDU-UHFFFAOYSA-N
mode of action cell membrane | interferes
optical activity [α]/D 20/D (Rotation: -2.3 +/- 0.2 degrees)
Quality Level 200 
solubility H2O: soluble 20 mg/mL
storage temp. 2-8°C
Application: Polymyxin B is used to study multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.
Biochem/physiol Actions: Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.

Mode of Resistance: The activity of Polymyxin B sulfate is inhibited by iron(II), Co(II), Mn(II) and Magnesium ions. Polymyxin B may also be incompaitible with other microbial agents, including amphoterecin, cephalothin sodium, cephasolin sodium and heparin sodium.

Antimicrobial Spectrum: Has bactericidal action on most gram-negative bacilli, including E. Coli and on most fungi and gram-positive bacteria.
General description: Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa.
Other Notes: Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Handle and store under inert gas.
Packaging: 10ml, 125ml
Preparation Note: This product is concentrated at 20 mg/mL in water, and should be stored at 2-8°C.
RIDADR NONH for all modes of transport
WGK Germany WGK 2
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. 2-8°C
UNSPSC 51101500

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