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(+)-Tubocurarine chloride pentahydrate

SIGMA/93750 - ≥97.0% (TLC)

Synonym: (+)-Tubocurarine chloride hydrochloride pentahydrate; D-Tubocurarine dichloride pentahydrate; Tubarine pentahydrate

CAS Number: 6989-98-6
Empirical Formula (Hill Notation): C37H42Cl2N2O6 · 5H2O
Molecular Weight: 771.72
MDL Number: MFCD00150157
Linear Formula: C37H42Cl2N2O6 · 5H2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-93750-250MG 250 mg
 $142.00
1/EA		 Add To Favorites
45-93750-1G 1 g
 $427.00
1/EA		 Add To Favorites

 

assay ≥97.0% (TLC)
biological source plant
form powder
impurities ~12% water
InChI 1S/C37H40N2O6.2ClH.5H2O/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;;;;;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H;5*1H2/t28-,29+;;;;;;;/m0......./s1
InChI key WMIZITXEJNQAQK-GGDSLZADSA-N
mp 275-280 °C (dec.) (lit.)
optical activity [α]20/D +195±5°, c = 0.5% in H2O
Quality Level 200 
SMILES string [Cl-].Cl[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].[H]O[H].COc1cc2CCN(C)[C@H]3Cc4ccc(Oc5c(O)c(OC)cc6CC[N+](C)(C)[C@H](Cc7ccc(O)c(Oc1cc23)c7)c56)cc4
storage temp. 2-8°C
Application: (+)-Tubocurarine chloride pentahydrate has been used:
• as an acetylcholine receptor antagonist in synapse blocking experiment to study its effect on neuromuscular junction formation (NMJ) formation in a co-culture system of human skeletal muscles and human stem cell-derived motoneurons
• to induce paralysis in zebrafish larvae to study whole-brain imaging of seizures by two-photon light-sheet microscopy
• to block NMJ to study its role in myotube contraction
Biochem/physiol Actions: (+)-Tubocurarine chloride pentahydrate serves as a neuromuscular blocker.
Biochem/physiol Actions: Classical competitive antagonist of the nicotinic acetylcholine receptor. Structure-activity relationships and conformational studies for tubocurarine binding at the nicotinic AChR.
Packaging: 1 g in poly tube
Packaging: 250 mg in poly bottle
Symbol GHS06  GHS06
Signal word Danger
Hazard statements H301
Precautionary statements P301 + P310
Hazard Codes T
Risk Statements 25
Safety Statements 22-36/37/39-45
RIDADR UN 1544PSN2 6.1 / PGIII
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97.0% (TLC)
mp 275-280 °C (dec.) (lit.)
Storage Temp. 2-8°C
UNSPSC 12352202

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