Uricase from Bacillus fastidiosus
SIGMA/94310 - lyophilized, ~9 U/mg
Synonym: Urate oxidase
CAS Number: 9002-12-4
MDL Number: MFCD00082126
Product Type: Chemical
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| application(s) | detection |
| biological source | Bacillus sp. (B. fastidiosus) |
| color | white to faint beige |
| concentration | 90—100% |
| form | powder |
| InChI | 1S/C18H23N4O14P.H3N/c23-5 |
| InChI key | VPXDHZMLJOJKOX-UHFFFAOYSA |
| quality | lyophilized |
| Quality Level | 300  |
| SMILES string | N.OCC1OC(C(O)C1OP(O)(=O)O |
| solubility | 5 mg/mL, clear, colorless to very faintly yellow (in enzyme dilution buffer) |
| specific activity | ~9 U/mg |
| storage condition | dry at room temperature |
| storage temp. | −20°C |
| Application: | Uricase may be used for the determination of uric acid in biological fluids. It may be helpful in the spectrophotometric determination of purines and purine nucleosides. |
| Biochem/physiol Actions: | Uricase catalyzes the oxidation of uric acid to 5-hydroxyisourate, which subsequently forms (S)-allantoin. It is involved in purine metabolism, urate degradation and (S)-allantoin formation The absence of functional uricase in humans has significant physiological and pathophysiological implications. It has been associated with higher serum uric acid levels, leading to an increased risk of conditions related to uric acid crystallization, such as gout. Uricase has emerged as an important therapeutic target for the treatment of conditions related to hyperuricemia, such as gout. |
| General description: | Research area: Cell signaling |
| General description: | Uricase is present in many organisms, such as, archaea, bacteria, and eukaryotes. The Gut microbiome is the major source of uricase, a homotetrameric enzyme containing four identical 34 kDa subunits. |
| Other Notes: | 1 U corresponds to the amount of enzyme which oxidizes 1 μmole uric acid at pH 9.1 and 37 °C. |
| Other Notes: | For the determination of uric acid in biological fluids; In the spectrophotometric determination of purines and purine nucleosides. |
| Symbol |  GHS08 |
| Signal word | Danger |
| Hazard statements | H319 - H334 - H360FD |
| Precautionary statements | P202 - P261 - P264 - P280 - P305 + P351 + P338 - P308 + P313 |
| Hazard Codes | T |
| Risk Statements | 60-61-42 |
| Safety Statements | 53-22-35-36/37-45 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| activity | specific activity: ~9 U/mg |
| Storage Temp. | −20°C |
| Enzyme Commission (EC) Number | 1.7.3.3 ( BRENDA  | IUBMB ) |
| UNSPSC | 12352204 |