Uridine 5′-diphosphate disodium salt hydrate

SIGMA/94330 - ≥96.0% (HPLC)

Synonym: UDP; 5′-UDP-Na₂

CAS Number: 27821-45-0
Empirical Formula (Hill Notation): C₉H₁₂N₂Na₂O₁₂P₂ · xH₂O
Molecular Weight: 448.12 (anhydrous basis)
EC Number: 248-678-9
MDL Number: MFCD00149253
Linear Formula: C₉H₁₂N₂Na₂O₁₂P₂ · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-94330-100MG	100 mg	$126.00 1/EA	Add To Favorites
45-94330-500MG	500 mg	$509.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥96.0% (HPLC)
biological source	synthetic
form	powder
impurities	≤15% water
InChI	1S/C9H14N2O12P2.2Na.H2O/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(22-8)3-21-25(19,20)23-24(16,17)18;;;/h1-2,4,6-8,13-14H,3H2,(H,19,20)(H,10,12,15)(H2,16,17,18);;;1H2/q;2*+1;/p-2/t4-,6-,7-,8-;;;/m1.../s1
InChI key	RHBXRWOXLRCWIZ-LLWADOMFSA-L
Quality Level	100
SMILES string	[Na+].[Na+].[H]O[H].O[C@H]1[C@@H](O)[C@@H](O[C@@H]1COP([O-])(=O)OP(O)([O-])=O)N2C=CC(=O)NC2=O
storage temp.	−20°C

Application:

Uridine 5′-diphosphate disodium salt hydrate has been used:
• as a standard for quantification of metabolite levels in murine tumor interstitial fluid by liquid chromatography-mass spectrometry (LC/MS)
• as a UDP standard for nucleotide analysis by liquid chromatography-high resolution mass spectrometry (LC-HRMS)
• to treat E6.5 retina explants in vitro, to study its effect on the entry and elongation of microglial cells into the embryonic quail retina

Biochem/physiol Actions:

Uridine 5′-diphosphate (UDP) is an endogenous signaling molecule produced by damaged cells to attract macrophages. In response to neuronal damage, UDP promotes chemotaxis and chemokinesis in microglial cells. UDP serves as a ligand for P2Y receptors. UDP and uridine 5′-triphosphate (UTP) may be used in studies on nucleic acid (RNA) biosynthesis and cell signaling. UDP is a nucleotide that upon phosphorylation to UTP becomes a substrate for enzymes such as RNA polymerase(s) and GTPases. These enzymes are involved in a wide range of applications from the synthesis of RNA to the regulation of G-coupled protein receptors (GPCR) and cell signaling molecules such as Rho-signaling via guanine nucleotide exchange factors (GEF).

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥96.0% (HPLC)
Storage Temp.	−20°C
UNSPSC	41106305

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