Poly(ethylene glycol)
SIGMA/94646 - BioUltra, 35,000
Synonym: Polyethylene glycol; PEG
CAS Number: 25322-68-3
MDL Number: MFCD00081839
Linear Formula: H(OCH2CH2)nOH
Product Type: Chemical
| λ | 50 mg/mL in H2O |
| anion traces | chloride (Cl-): ≤50 mg/kg |
| sulfate (SO42-): ≤50 mg/kg | |
| cation traces | Al: ≤5 mg/kg |
| As: ≤0.1 mg/kg | |
| Ba: ≤5 mg/kg | |
| Bi: ≤5 mg/kg | |
| Ca: ≤10 mg/kg | |
| Cd: ≤5 mg/kg | |
| Co: ≤5 mg/kg | |
| Cr: ≤5 mg/kg | |
| Cu: ≤5 mg/kg | |
| Fe: ≤5 mg/kg | |
| K: ≤200 mg/kg | |
| Li: ≤5 mg/kg | |
| Mg: ≤5 mg/kg | |
| Mn: ≤5 mg/kg | |
| Mo: ≤5 mg/kg | |
| Na: ≤200 mg/kg | |
| Ni: ≤5 mg/kg | |
| Pb: ≤5 mg/kg | |
| Sr: ≤5 mg/kg | |
| Zn: ≤5 mg/kg | |
| form | powder or crystals (or flakes) |
| impurities | insoluble matter:, passes filter test |
| ≤0.005% peroxides (as H2O2): | |
| InChI | 1S/C2H6O2/c3-1-2-4/h3-4H, |
| InChI key | LYCAIKOWRPUZTN-UHFFFAOYSA |
| mol wt | Mr ~35000 |
| mp | 64-66 °C |
| pH | 5.5-7.0 (25 °C, 50 mg/mL in H2O) |
| product line | BioUltra |
| Quality Level | 200  |
| SMILES string | C(CO)O |
| solubility | H2O: 50 mg/mL at 25 °C, clear, colorless |
| UV absorption | λ: 260 nm Amax: 0.12 |
| λ: 280 nm Amax: 0.12 |
| Application: | Poly(ethylene glycol) has been used: • as a component of University of Wisconsin (UW) cold preservation solutions to stabilize the cell membrane of hepatocytes during temperature changes • as a component of the supercooling solution to study supercooling preservation technique of the rat liver for transplantation and to protect against hypothermic injury • to prepare aqueous phase for the fabrication of multicellular spheroid (MCS) cultures |
| Biochem/physiol Actions: | Polyethylene glycol (PEG) is a synthetic polymer that is used as a gold standard in bioconjugation and nanomedicine to extend blood circulation time and enhance drug efficacy. It acts as an ice-modulator by preventing ice crystallization, which is beneficial for cellular membranes. PEG provides protection against hypothermic injury, like lipid peroxidation and cell membrane injury. PEG-conjugated drugs are considered safe for use in humans and are approved by the U.S. Food and Drug Administration (FDA). PEG has several biomedical applications, including biosensing, imaging, and tissue engineering. It also repels protein adsorption and lowers the liver uptake, which helps in coating nanoparticles. |
| General description: | Polyethylene glycol (PEG) is a polyether compound that is used as an additive in cosmetics, pharmaceuticals, and food. It consists of repeated ethylene glycol units[-(CH2CH2O)n]. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | 281.5 °F - closed cup |
| Flash Point(C) | 138.6 °C - closed cup |
| mp | 64-66 °C |
| UNSPSC | 12352104 |