Vitamin K1
SIGMA/95271 - BioXtra, ≥99.0% (sum of isomers, HPLC), mixture of isomers
Synonym: 2-
CAS Number: 84-80-0
Empirical Formula (Hill Notation): C31H46O2
Molecular Weight: 450.70
EC Number: 201-564-2
MDL Number: MFCD00214063
Linear Formula: C31H46O2
Product Type: Chemical
| assay | ≥99.0% (sum of isomers, HPLC) |
| biological source | synthetic |
| cation traces | Al: ≤5 mg/kg |
| Ba: ≤5 mg/kg | |
| Bi: ≤5 mg/kg | |
| Ca: ≤10 mg/kg | |
| Cd: ≤5 mg/kg | |
| Co: ≤5 mg/kg | |
| Cr: ≤5 mg/kg | |
| Cu: ≤5 mg/kg | |
| Fe: ≤5 mg/kg | |
| K: ≤100 mg/kg | |
| Li: ≤5 mg/kg | |
| Mg: ≤5 mg/kg | |
| Mn: ≤5 mg/kg | |
| Mo: ≤5 mg/kg | |
| Na: ≤10 mg/kg | |
| Ni: ≤5 mg/kg | |
| Pb: ≤5 mg/kg | |
| Sr: ≤5 mg/kg | |
| Zn: ≤5 mg/kg | |
| color | light green-yellow to dark green-yellow |
| light yellow to dark yellow | |
| density | 0.984 g/mL at 25 °C (lit.) |
| form | viscous liquid |
| ign. residue | ≤0.1% (as SO4) |
| impurities | ≤20% cis-isomer |
| InChI | 1S/C31H46O2/c1-22(2)12-9- |
| InChI key | MBWXNTAXLNYFJB-NKFFZRIASA |
| mp | −20 °C (lit.) |
| product line | BioXtra |
| Quality Level | 200  |
| refractive index | n |
| SMILES string | O=C(C1=CC=CC=C21)C(C)=C(C |
| storage temp. | 2-8°C |
| Application: | <ul><BR/><li><strong>Nutritional strategies for musculoskeletal health:</strong> Nutritional strategies, including Vitamin K1, optimize musculoskeletal health for fall and fracture prevention beyond traditional nutrients like calcium and vitamin D (Webster et al., 2023 <A class="External" onClick="cmCreateManualPageviewTag('doi.org - 95271 SIGMA', 'EXTERNAL LINKS', 'https://doi.org/10.1016/j.bonr.2023.101684', window.location);" rel="nofollow" href="https://doi.org/10.1016/j.bonr.2023.101684">doi:10.1016/j.bonr.2023.1<WBR>01684</A><img src="/images/pixel.png">).</li><BR/><li><strong>Role in coagulation and bone health:</strong> A comprehensive review highlights Vitamin K1′s role in reducing cardiovascular risks and details its biochemical interactions affecting coagulation and bone health (Zhao et al., 2024 <A class="External" onClick="cmCreateManualPageviewTag('doi.org - 95271 SIGMA', 'EXTERNAL LINKS', 'https://doi.org/10.1017/jns.2023.106', window.location);" rel="nofollow" href="https://doi.org/10.1017/jns.2023.106">doi:10.1017/jns.2023.106</A><img src="/images/pixel.png">).</li><BR/></ul><BR/> |
| Biochem/physiol Actions: | Vitamin K1 (Phylloquinone) is a lipid soluble polycyclic aromatic ketone used as a cofactor in the formation of coagulation factors II (prothrombin), VII, IX and X; anticoagulant factors protein C and S and as a cell signaling factor. |
| Biochem/physiol Actions: | Vitamin K1 plays a role as a cofactor in the synthesis of γ- carboxy glutamate (Gla), formation of coagulation factors II (prothrombin), VII, IX and X. |
| General description: | Vitamin K1, also known as phylloquinone, consists of naphthalenoid and phytyl groups. Phylloquinone is present abundantly in photosynthetic plants and is a major dietary source. It is a fat-soluble vitamin. |
| Other Notes: | Review: Vitamin K and γ-carboxyglutamate biosynthesis; Metabolic functions and mechanism of action |
| Packaging: | Bottomless glass bottle. Contents are inside inserted fused cone. |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 2 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥99.0% (sum of isomers, HPLC) |
| mp | −20 °C (lit.) |
| Density | 0.984 g/mL at 25 °C (lit.) |
| Refractive Index | n |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352205 |