AS605240
SIGMA/A0233 - ≥98% (HPLC)
Synonym: 5-
CAS Number: 648450-29-7
Empirical Formula (Hill Notation): C12H7N3O2S
Molecular Weight: 257.27
MDL Number: MFCD11100415
Linear Formula: C12H7N3O2S
Product Type: Chemical
| assay | ≥98% (HPLC) |
| color | , faint red to orange to dark brown |
| form | powder |
| InChI | 1S/C12H7N3O2S/c16-11-10(1 |
| InChI key | SQWZFLMPDUSYGV-POHAHGRESA |
| Quality Level | 100  |
| SMILES string | O=C1NC(=O)C(S1)=Cc2ccc3 |
| solubility | DMSO: 1 mg/mL, clear (warmed) |
| storage temp. | 2-8°C |
| Application: | AS605240 has been used: • as a phosphatidylinositol 3-kinase (PI3K) inhibitor to study its effect on Rab5-positive early endosome (EE) vesicles. • as a (PI3K) inhibitor to treat splenocytes for graft-versus-host disease (GVHD) induction. • as a class 1A PI3K inhibitor to treat CD4+ T cells. |
| Biochem/physiol Actions: | AS605240 inhibits human recombinant phosphatidylinositol 3-kinase (PI3K) γ, α, β, and δ by competing with adenosine triphosphate (ATP). It plays a role in protecting injury following ischemic stroke. AS605240 also inhibits the activation of astrocytes under the influence of Interleukin-6 (IL-6) and its soluble receptor (sIL-6R). It reduces collagen deposition and prevents lung inflammation. AS605240 also inhibits the increase of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) expression instigated by bleomycin. It is effective in preventing pulmonary fibrosis by inhibiting the transforming growth factor β1 (TGF-β1) and T lymphocytes infiltration into lungs. |
| Biochem/physiol Actions: | AS605240 is a potent and selective PI3Kγ inhibitor. |
| Features and Benefits: | This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: | This compound is featured on the Phosphoinositide Kinases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |