N-Acetyl-Asp-Glu-Val-Asp-7-amido-4-trifluoromethylcoumarin

SIGMA/A0466 - ≥90% (HPLC), powder

Synonym: Ac-DEVD-AFC

CAS Number: 201608-14-2
Empirical Formula (Hill Notation): C₃₀H₃₄F₃N₅O₁₃
Molecular Weight: 729.61
MDL Number: MFCD01310970
Linear Formula: C₃₀H₃₄F₃N₅O₁₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-A0466-1MG	1 mg	$191.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥90% (HPLC)
color	white
form	powder
InChI	1S/C30H34F3N5O13/c1-12(2)25(38-26(47)17(6-7-21(40)41)36-28(49)18(10-22(42)43)34-13(3)39)29(50)37-19(11-23(44)45)27(48)35-14-4-5-15-16(30(31,32)33)9-24(46)51-20(15)8-14/h4-5,8-9,12,17-19,25H,6-7,10-11H2,1-3H3,(H,34,39)(H,35,48)(H,36,49)(H,37,50)(H,38,47)(H,40,41)(H,42,43)(H,44,45)/t17-,18-,19-,25-/m0/s1
InChI key	GZDRODOYEFEHGG-NUDCOPPTSA-N
Quality Level	200
SMILES string	CC(C)[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H](CC(O)=O)C(=O)Nc1ccc2c(OC(=O)C=C2C(F)(F)F)c1
solubility	H₂O: 1 mg/mL
storage temp.	−20°C

Amino Acid Sequence:	NAc-Asp-Glu-Val-Asp-AFC
Biochem/physiol Actions:	A fluorogenic substrate for caspase 3, a protease that is rapidly activated when cells are exposed to apoptotic conditions and that cleaves poly(ADP-ribose) polymerase. The 7-amido-4-trifluoromethylcoumarin derivative has better membrane permeability than the 7-amido-4-methylcoumarin derivative (A1086).
Biochem/physiol Actions:	A fluorogenic substrate for caspase 3; has better membrane permeability than the 7-amido-4-methylcoumarin derivative (A1086).
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥90% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352209

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